Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송무곤 | - |
dc.date.accessioned | 2018-03-13T09:59:48Z | - |
dc.date.available | 2018-03-13T09:59:48Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Cancer Science, 104, 12, 1656-1661 | en_US |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.issn | 1349-7006 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/cas.12282/full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/46330 | - |
dc.description.abstract | Recent studies have shown that metabolic tumor volume (MTV) by positron emission tomography/computed tomography (PET/CT) is an important prognostic parameter in patients with non-Hodgkin's lymphoma. However, it is unknown whether doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) alone in early stage Hodgkin's lymphoma would lead to similar disease control as combined modality therapy (CMT) using MTV by PET/CT. One hundred and twenty-seven patients with early stage Hodgkin's lymphoma who underwent PET/CT at diagnosis were enrolled. The MTV was delineated on PET/CT by the area ≥SUVmax, 2.5 (standardized uptake value [SUV]). Sixty-six patients received six cycles of ABVD only. The other 61 patients received CMT (involved-field radiotherapy after 4?6 cycles of ABVD). The calculated MTV cut-off value was 198 cm3. Clinical outcomes were compared according to several prognostic factors (i.e. age ≥50 years, male, performance status ≥2, stage II, B symptoms, ≥4 involved sites, extranodal site, large mediastinal mass, CMT, elevated erythrocyte sedimentation rate and high MTV). Older age (progression-free survival [PFS], P = 0.003; overall survival [OS], P = 0.007), B symptoms (PFS, P = 0.006; OS, P = 0.036) and high MTV (PFS, P = 0.008; OS, P = 0.007) were significant independent prognostic factors. Survival of two high MTV groups treated with ABVD only and CMT were lower than the low MTV groups (PFS, P < 0.012; OS, P < 0.045). ABVD alone was sufficient to control disease in those with low MTV status. However, survival was poor, even if the CMT was assigned a high MTV status. The MTV would be helpful for deciding the therapeutic modality in patients with early stage Hodgkin's lymphoma. | en_US |
dc.description.sponsorship | The present study was supported by grants from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea (0920050) and the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A070001). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Japanese Cancer Association | en_US |
dc.subject | Adolescent | en_US |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | en_US |
dc.subject | therapeutic use | en_US |
dc.subject | Bleomycin | en_US |
dc.subject | Dacarbazine | en_US |
dc.subject | Disease-Free Survive | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | Fluorodeoxyglucose F18 | en_US |
dc.subject | Hodgkin Disease | en_US |
dc.title | Metabolic tumor volume by positron emission tomography/computed tomography as a clinical parameter to determine therapeutic modality for early stage Hodgkin's lymphoma. | en_US |
dc.title.alternative | computed tomography as a clinical parameter to determine therapeutic modality for early stage Hodgkin's lymphoma. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/cas.12282 | - |
dc.relation.journal | CANCER SCIENCE | - |
dc.contributor.googleauthor | Song, Moo-Kon | - |
dc.contributor.googleauthor | Chung, Joo-Seop | - |
dc.contributor.googleauthor | Lee, Je-Jung | - |
dc.contributor.googleauthor | Jeong, Shin Young | - |
dc.contributor.googleauthor | Lee, Sang-Min | - |
dc.contributor.googleauthor | Hong, Jun-Shik | - |
dc.contributor.googleauthor | Chong, Ari | - |
dc.contributor.googleauthor | Moon, Joon-Ho | - |
dc.contributor.googleauthor | Kim, Ji-Hyun | - |
dc.contributor.googleauthor | Lee, Seok-Mo | - |
dc.relation.code | 2013009315 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | song9676 | - |
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