Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용순 | - |
dc.date.accessioned | 2018-03-13T05:43:13Z | - |
dc.date.available | 2018-03-13T05:43:13Z | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | 대한폐경학회지, 2012, 19(1), P.1-8 | en_US |
dc.identifier.issn | 2288-6478 | - |
dc.identifier.uri | http://kiss.kstudy.com/thesis/thesis-view.asp?key=3138826 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45984 | - |
dc.description.abstract | Objectives: Phytoestrogen-containing pulse supplements have beneficial effects on postmenopausal symptoms, but how such effects are achieved is unclear. This study investigates the effects of pulse consumption on the menopausal changes in ovariectomized rats. Methods: Female Sprague-Dawley rats were either sham operated (Sham; n = 3) or surgically ovariectomized (n = 13). The Sham group was fed the regular AIN-93M diet. Ovariectomized group was divided into 3 sub-groups and fed AIN-93M containing soybean (n = 5), mung bean (n = 3), or cowpea (n = 5) for 10 weeks. At the end of the experiment, all rats were sacrificed, and the uterus was harvested, rinsed, and weighed. Expressions of vitamin D receptor (VDR), estrogen receptor (ER) β, and ezrin in uterus were evaluated by immunohistochemistry. Results: VDR was highly expressed in the uterus of rat, irrespective of ovariectomized state. VDR was more definitely expressed in the uterus of ovariectomized groups than the sham-operated group. There were no significant differences in expression of ER β. However the expression of ezrin was highly expressed in the cowpea group compared to sham group (P = 0.044). Conclusion: This study suggested that legumes diet may concern menopausal changes via VDR and ezrin. The result may partly explain the beneficial effects of VDR on menopausal symptoms. Further study is necessary to study the detailed mechanisms of VDR and ezrin on the menopausal changes in the uterus. | en_US |
dc.description.sponsorship | 본 연구는 2012년 대한폐경학회 청화 학술상으로 진행된 과제입니다. 본 연구에는 어떠한 이해의 충돌도 관여하지 않았습니다. | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한폐경학회 | en_US |
dc.subject | Menopause | en_US |
dc.subject | Receptors calcitriol | en_US |
dc.subject | Uterus | en_US |
dc.title | 폐경 쥐 모델에서 두류 섭취에 따른 자궁의 비타민 D 수용체의 발현 | en_US |
dc.type | Article | en_US |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.6118/jksm.2013.19.1.1 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | 대한폐경학회지 | - |
dc.contributor.googleauthor | 김태희 | - |
dc.contributor.googleauthor | 박준식 | - |
dc.contributor.googleauthor | 이해혁 | - |
dc.contributor.googleauthor | 이우석 | - |
dc.contributor.googleauthor | 정수호 | - |
dc.contributor.googleauthor | 박용순 | - |
dc.contributor.googleauthor | 변동원 | - |
dc.contributor.googleauthor | Kim, Tae-Hee | - |
dc.contributor.googleauthor | Park, Jun-Sik | - |
dc.contributor.googleauthor | Lee, Hae-Hyeog | - |
dc.contributor.googleauthor | Lee, Woo Seok | - |
dc.contributor.googleauthor | Chung, Soo Ho | - |
dc.contributor.googleauthor | Park, Yong Soon | - |
dc.contributor.googleauthor | Byun, Dong Won | - |
dc.relation.code | 2012232691 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | DEPARTMENT OF FOOD & NUTRITION | - |
dc.identifier.pid | yongsoon | - |
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