Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
- Title
- Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
- Author
- 박용수
- Keywords
- Gestational diabetes mellitus; Gestational impaired glucose tolerance; Insulin secretion; Insulin resistance
- Issue Date
- 2013-06
- Publisher
- KOREAN ASSOCIATION OF INTERNAL MEDICINE
- Citation
- The Korean journal of internal medicine : KJIM , 2013, 28(3), pp.306 - 313
- Abstract
- Background/AimsThe aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM).MethodsA cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose ≥ 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281).ResultsThe GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin sensitivity check index, homeostasis model assessment for estimation of index β-cell secretion (HOMA-B), first and second phase insulin secretion, and insulin secretion-sensitivity index (ISSI) than the NGT group (p ≤ 0.001 for all). Moreover, the GIGT group had lower ISOGTT, HOMA-B, first and second phase insulin secretion, and ISSI than the NGT group (p < 0.001 for all). Among the GIGT subjects, the 1-hour plasma glucose abnormal levels group showed significantly greater weight gain during pregnancy and higher values in the 50-g OGCT than the other two groups. Moreover, the 1-hour and 2-hour abnormal levels groups had poorer insulin secretion status than the 3-hour abnormal levels group.ConclusionsKorean women with GDM show impairments of both insulin secretion and insulin sensitivity. In addition, GIGT is associated with both β-cell dysfunction and insulin resistance.
- URI
- http://kjim.org/journal/view.php?doi=10.3904/kjim.2013.28.3.306http://hdl.handle.net/20.500.11754/45977
- ISSN
- 1226-3303
- DOI
- 10.3904/kjim.2013.28.3.306
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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