Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정희경 | - |
dc.date.accessioned | 2018-03-13T05:34:13Z | - |
dc.date.available | 2018-03-13T05:34:13Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Anticancer Research, Vol.33, No.12 [2013], p5445-5452 | en_US |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | http://ar.iiarjournals.org/content/33/12/5445.short | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45965 | - |
dc.description.abstract | Background/Aim: Lobarstin is a metabolite occurring from the Antarctic lichen Stereocaulon alpnum. Human glioblastoma is highly resistant to chemotherapy with temozolomide. Lobarstin was examined for its effect on glioblastoma. Materials and Methods: Temozolomide-resistant T98G cells were subjected to toxicity test with temozolomide and/or lobarstin. DNA damage and recovery was assessed by the alkaline comet assay and expression of DNA repair genes was examined by RT-PCR and western blot analysis. Results: Lobarstin alone at 40 mu M was toxic against T98G, but had no effect in primary human fibroblasts. Co-treatment of lobarstin with temozolomide yielded enhanced toxicity. Temozolomide-alone or with lobarstin co-treatment gave similar extent of DNA damage. However, the recovery was reduced in co-treated cells. Expression of DNA repair genes, O-6-methylguanine-DNA methyltransferase, poly(ADPribose) polymerase I and ligase 3 were reduced in lobarstin-treated cells. Conclusion: Enhanced sensitivity to temozolomide by lobarstin co-treatment may be attributed to reduced DNA repair. | en_US |
dc.description.sponsorship | This research was a part of the project titled "Korea-Polar Ocean Development: K-POD" (project no. PM12030) funded by the Ministry of Oceans and Fisheries, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH | en_US |
dc.subject | Lobarstin | en_US |
dc.subject | glioblastoma | en_US |
dc.subject | temozolomide | en_US |
dc.subject | chemosensitivity | en_US |
dc.subject | DNA repair | en_US |
dc.title | Lobarstin Enhances Chemosensitivity in Human Glioblastoma T98G Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 33 | - |
dc.relation.page | 5445-5451 | - |
dc.relation.journal | ANTICANCER RESEARCH | - |
dc.contributor.googleauthor | Kim, S. | - |
dc.contributor.googleauthor | Jo, S. | - |
dc.contributor.googleauthor | Lee, H. | - |
dc.contributor.googleauthor | Kim, T.U. | - |
dc.contributor.googleauthor | Kim, I.C. | - |
dc.contributor.googleauthor | Yim, J.H. | - |
dc.contributor.googleauthor | Chung, H. | - |
dc.relation.code | 2013008942 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hc2n | - |
dc.identifier.researcherID | 7404006418 | - |
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