Influence ofAPOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly
- Title
- Influence ofAPOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly
- Author
- 이종민
- Keywords
- APOLIPOPROTEIN-E EPSILON-4; POSITRON-EMISSION-TOMOGRAPHY; GRAPH-THEORETICAL ANALYSIS; ALZHEIMERS-DISEASE; GENETIC RISK; TOPOLOGICAL PATTERNS; BLOOD-FLOW; ALLELE; MRI; CARRIERS
- Issue Date
- 2013-12
- Publisher
- Public Library Science
- Citation
- PLOS ONE, 2013, 8(12), P.1-9
- Abstract
- This study aimed to investigate the influence of apolipoprotein E (APOE) epsilon 4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE epsilon 4 carriers (epsilon 4+) and 58 non-carriers (epsilon 4-)] underwent clinical evaluation and resting [F-18] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in epsilon 4- was preserved in epsilon 4+. However, both local clustering and path length were lower in epsilon 4+ compared to epsilon 4-. In terms of the hubs of functional networks, epsilon 4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to epsilon 4-. Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear.
- URI
- http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083205
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0083205
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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