Nutritional regulation of stem and progenitor cells in Drosophila
- Title
- Nutritional regulation of stem and progenitor cells in Drosophila
- Author
- 심지원
- Keywords
- Drosophila; Insulin; Dilp; Germline stem cell; Intestinal stem cell; Hematopoietic progenitor cell; Neural stem cell; Amino acid sensing; Nutritional control
- Issue Date
- 2013-12
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Citation
- DEVELOPMENT, 140, 23, p4647-p4656
- Abstract
- Stem cells and their progenitors are maintained within a microenvironment, termed the niche, through local cell-cell communication. Systemic signals originating outside the niche also affect stem cell and progenitor behavior. This review summarizes studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila. Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within the niche. The concept of systemic control of these cell types is not limited to Drosophila and may be functional in vertebrate systems, including mammals.
- URI
- http://dev.biologists.org/content/140/23/4647.shorthttp://hdl.handle.net/20.500.11754/45770
- ISSN
- 0950-1991
- DOI
- 10.1242/dev.079087
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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