Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease
- Title
- Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer's disease
- Author
- 이종민
- Keywords
- Alzheimer's disease; Onset age; Early onset; Cortical thickness; Longitudinal study
- Issue Date
- 2013-07
- Publisher
- ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
- Citation
- NEUROBIOLOGY OF AGING 권: 34 호: 7
- Abstract
- Early-onset Alzheimer's disease (EOAD) has been shown to progress more rapidly than late-onset Alzheimer's disease (LOAD). However, no studies have compared the topography of brain volume reduction over time. The purpose of this 3-year longitudinal study was to compare EOAD and LOAD in terms of their rates of decline in cognitive testing and topography of cortical thinning. We prospectively recruited 36 patients with AD (14 EOAD and 22 LOAD) and 14 normal controls. All subjects were assessed with neuropsychological tests and with magnetic resonance imaging at baseline, Year 1, and Year 3. The EOAD group showed more rapid decline than the LOAD group in attention, language, and frontal-executive tests. The EOAD group also showed more rapid cortical thinning in widespread association cortices. In contrast, the LOAD group presented more rapid cortical thinning than the EOAD group only in the left parahippocampal gyrus. Our study suggests that patients with EOAD show more rapid cortical atrophy than patients with LOAD, which accounts for faster cognitive decline on neuropsychological tests. (C) 2013 Elsevier Inc. All rights reserved.
- Description
- Ministry of Health and Welfare, Republic of Korea
- URI
- http://dx.doi.org/10.1016/j.neurobiolaging.2013.01.004http://hdl.handle.net/20.500.11754/45600
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2013.01.004
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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