Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
- Title
- Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
- Author
- 이종민
- Keywords
- Cognitive function; Epilepsy; Levetiracetam; Antiepileptic drug; Neuropsychological test
- Issue Date
- 2013-07
- Publisher
- S. Karger AG
- Citation
- EUROPEAN NEUROLOGY, 권: 70, 호: 1-2, 페이지: 88-94
- Abstract
- Aims:To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. Methods: Fifty-five drug-naive epilepsy patients (M:F ratio = 31:24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 +/- 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. Results: LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomotor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. Conclusion: Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naive patients with epilepsy. Copyright (C) 2013 S. Karger AG, Basel
- URI
- https://www.karger.com/Article/Abstract/347230http://hdl.handle.net/20.500.11754/45594
- ISSN
- 0014-3022; 1421-9913
- DOI
- 10.1159/000347230
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML