Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas
- Title
- Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas
- Author
- 오영하
- Keywords
- Small intestine; Carcinoma; Immunohistochemistry; Insulin-like growth factor system; Insulin-like growth; factor?1; Insulin-like growth factor 1 receptor
- Issue Date
- 2013-05
- Publisher
- KARGER
- Citation
- Pathobiology, 2013, 80(5), P.265-270
- Abstract
- Objective: The insulin-like growth factor (IGF) system has been known to play a critical role in tumor development and progression in many human cancers. However, the role of the IGF system in small intestinal carcinoma (SIC) has not been studied yet. Methods: We evaluated the expression of IGF1 and IGF1 receptor (IFG1R) in a total of 194 cases of SIC. Results: IGF1 expression was associated with well/moderate differentiation, better survival, lower pT, lower stage and no lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors with lower pT and lower stage. Conclusions: IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not have a major therapeutic role in treating SIC.
- URI
- https://www.karger.com/Article/Abstract/350309http://hdl.handle.net/20.500.11754/44699
- ISSN
- 1015-2008; 1423-0291
- DOI
- 10.1159/000350309
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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