Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 백승삼 | - |
dc.date.accessioned | 2018-03-03T04:31:48Z | - |
dc.date.available | 2018-03-03T04:31:48Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | CLINICA CHIMICA ACTA; OCT 9 2011, 412 21-22, p1978-p1982 | en_US |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.issn | 1873-3492 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0009898111003858?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffb | - |
dc.description.abstract | Background: We evaluated whether direct tissue matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) analysis of lipids may distinguish intrahepatic cholangiocarcinomas from adjacent normal tissue and from other adenocarcinomas that frequently metastasize to liver.Methods: Four pairs of frozen surgical specimens of cholangiocarcinomas and adjacent normal tissue were analyzed using histology-directed, MALDI MS analysis. 2,5-dihydroxybenzoic acid / alpha-cyano-4-hydroxycinnamic acid were manually deposited on tumor-rich areas, and mass spectra were acquired using a MALDI-time of flight instrument.Results: Cholangiocarcinomas and adjacent normal tissue samples demonstrated different lipid profiles, as evidenced by permutation P value < 0.05 for the cross-validated misclassification rate. Cancer-associated lipid alteration was similar between cholangiocarcinomas and pancreatic cancers, but not between cholangiocarcinomas and colorectal cancers. Baseline lipid profiles were different between cholangiocarcinoma and colorectal cancers.Conclusions: MALDI MS analysis of lipid distinguishes cancerous epithelium of cholangiocarcinoma from adjacent normal tissue, and between cholangiocarcinomas and colorectal cancers. (C) 2011 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | The work was supported by Converging Research Center Program through the Ministry of Education, Science and Technology of Korea (2010K001121) and by National Cancer Center Grant 0910570. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS | en_US |
dc.subject | Lipid | en_US |
dc.subject | Cholangiocarcinoma | en_US |
dc.subject | MALDI | en_US |
dc.title | Lipid profiles for intrahepatic cholangiocarcinoma identified using matrix-assisted laser desorption/ionization mass spectrometry | en_US |
dc.type | Article | en_US |
dc.relation.no | 21-22 | - |
dc.relation.volume | 412 | - |
dc.identifier.doi | 10.1016/j.cca.2011.07.008 | - |
dc.relation.page | 1978-1982 | - |
dc.relation.journal | CLINICA CHIMICA ACTA | - |
dc.contributor.googleauthor | Yoo, Chong Woo | - |
dc.contributor.googleauthor | Lee, Seok Cheol | - |
dc.contributor.googleauthor | Park, Sang Jae | - |
dc.contributor.googleauthor | Oh, Jae Hwan | - |
dc.contributor.googleauthor | Yoo, Byong Chul | - |
dc.contributor.googleauthor | Kim, Hark Kyun | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Lee, Kyeong Geun | - |
dc.contributor.googleauthor | Choi, Dongho | - |
dc.contributor.googleauthor | Kim, Song Cheol | - |
dc.relation.code | 2011201963 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sspaik | - |
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