When a ribosome encounters a premature termination codon
- Title
- When a ribosome encounters a premature termination codon
- Author
- 황정욱
- Keywords
- NAS; NMD; NMTGS; NMTR; PTC
- Issue Date
- 2013-01
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Citation
- BMB Reports, 2013, 46(1), P.9-16
- Abstract
- In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation. Truncated polypeptides synthesized from these aberrant transcripts could be toxic to normal cellular functions. However, mammalian cells have evolved sophisticated mechanisms for monitoring the quality of mRNAs. The faulty transcripts harboring PTC are subject to nonsense-mediated mRNA decay (NMD), nonsense-mediated translational repression (NMTR), nonsense-associated alternative splicing (NAS), or nonsense-mediated transcriptional gene silencing (NMTGS). In this review, we briefly outline the molecular characteristics of each pathway and suggest mRNA quality control mechanisms as a means to regulate normal gene expression. [BMB Reports 2013; 46(1): 9-16]
- URI
- http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2013_v46n1_9http://hdl.handle.net/20.500.11754/41446
- ISSN
- 1976-6696
- DOI
- 10.5483/BMBRep.2013.46.1.002
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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