Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영열 | - |
dc.date.accessioned | 2018-02-28T08:21:28Z | - |
dc.date.available | 2018-02-28T08:21:28Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | CELL TRANSPLANTATION, 21, 8, 1687~1783 | en_US |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | http://journals.sagepub.com/doi/10.3727/096368912X653039 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41346 | - |
dc.description.abstract | Human amniotic epithelial cells (h-AECs), which have various merits as a cell source for cell therapy, are known to differentiate into cardiomyocytes in vitro. However, the ability of h-AECs to differentiate into cardiomyocytes in vivo and their cell transplantation effects on myocardial infarction are still unknown. In this study, we assessed whether h-AECs could differentiate into cardiomyocytes in vivo and whether h-AECs transplantation can decrease infarct size and improve cardiac function, in comparison to transplantation of cord blood-derived mesenchymal stem cells (MSCs) or adipose tissue-derived MSCs. For our study, we injected h-AECs, cord blood-derived MSCs, adipose tissue-derived MSCs, and saline into areas of myocardial infarction in athymic nude rats. After 4 weeks, 3% of the surviving h-AECs expressed myosin heavy chain, a marker specific to the myocardium. Compared with the saline group, all cell-implanted groups showed a higher ejection fraction, lower infarct area by positron emission tomography and histology, and more abundant myocardial gene and protein expression in the infarct area. We showed that h-AECs can differentiate into cardiomyocyte-like cells, decrease infarct size, and improve cardiac function in vivo. The beneficial effects of h-AECs were comparable to those of cord blood and adipose tissue-derived MSCs. These results support the need for further studies of h-AECs as a cell source for myocardial regeneration due to their plentiful availability, low immunity, and lack of ethical issues related to their use. | en_US |
dc.description.sponsorship | This work was supported by the grant for the Medical Research Center (2011-0028261) funded by the National Research Foundation (NRF) of the Ministry of Education, Science and Technology (MEST), Republic of Korea. We thank Kyung-Sun Kang (Seoul National University, Korea) for providing human cord blood-derived mesenchymal stem cells. The authors declare no conflicts of interest. | en_US |
dc.language.iso | en | en_US |
dc.publisher | COGNIZANT COMMUNICATION CORP, 18 PEEKSKILL HOLLOW RD, PO BOX 37, PUTNAM VALLEY, NY 10579 USA | en_US |
dc.subject | Human amniotic epithelial cells | en_US |
dc.subject | Cardiomyocytes | en_US |
dc.subject | Differentiation | en_US |
dc.subject | Myocardial infarction | en_US |
dc.subject | LEFT-VENTRICULAR FUNCTION | en_US |
dc.subject | IMPROVES CARDIAC-FUNCTION | en_US |
dc.subject | SKELETAL MYOBLASTS | en_US |
dc.subject | THERAPY | en_US |
dc.subject | REPAIR | en_US |
dc.subject | MODEL | en_US |
dc.subject | HEART | en_US |
dc.subject | ANGIOGENESIS | en_US |
dc.subject | REGENERATION | en_US |
dc.subject | MULTIPOTENT | en_US |
dc.title | In Vivo Differentiation of Human Amniotic Epithelial Cells Into Cardiomyocyte-Like Cells and Cell Transplantation Effect on Myocardial Infarction in Rats: Comparison With Cord Blood and Adipose Tissue-Derived Mesenchymal Stem Cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.3727/096368912X653039 | - |
dc.relation.page | 1687-1696 | - |
dc.relation.journal | CELL TRANSPLANTATION | - |
dc.contributor.googleauthor | Fang, Cheng-Hu | - |
dc.contributor.googleauthor | Jin, Jiyong | - |
dc.contributor.googleauthor | Joe, Jun-Ho | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | So, Byung-Im | - |
dc.contributor.googleauthor | Lim, Sang-Moo | - |
dc.contributor.googleauthor | Cheon, Gi-Jeong | - |
dc.contributor.googleauthor | Woo, Sang-Keun | - |
dc.contributor.googleauthor | Ra, Jeong-Chan | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.relation.code | 2012201746 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leeyy | - |
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