Probiotic suppression of the H-pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line
- Title
- Probiotic suppression of the H-pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line
- Author
- 김정목
- Keywords
- Helicobacter pylori; Probiotics; Conjugated linoleic acids; Interleukin-8; Tumor necrosis factor-alpha; Inducible nitric oxide synthase
- Issue Date
- 2012-06
- Publisher
- Elsevier Science B.V., Amsterdam
- Citation
- Prostaglandins, leukotrienes, and essential fatty acids,Vol.86 No.6 [2012],p225-231
- Abstract
- Conjugated linoleic acids (CLA) produced by Lactobacillus acidophilus was reported to decrease the activation of nuclear factor-kappa B. CLA was suggested as one of the anti-inflammatory molecular mechanisms of probiotics. In the present study, the effects of CLA on H. pylori-induced multiple responses were evaluated. IL-8, TNF-alpha and iNOS were measured in mRNA and/or protein levels in AGS cells after pretreatment with CLA or CLA-containing conditioned medium (CM) produced by Lactobacillus acidophilus or Lactobacillus plantarum. The increased expressions of IL-8 mRNA/protein and TNF-alpha mRNA were significantly suppressed by pretreatment with CM or CLA. The levels of IL-8 protein and TNF-alpha mRNA were suppressed by CM pretreatment better than CLA. The expression of iNOS mRNA was also significantly inhibited by CM pretreatment. These results suggest that the suppression of multiple mediators by CLA-containing CM plays a key role in the anti-inflammatory and anti-carcinogenic effects of probiotics on H. pylori infection. (c) 2012 Elsevier Ltd. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0952327812000452?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffbhttp://hdl.handle.net/20.500.11754/40183
- ISSN
- 0952-3278
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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