Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조석현 | - |
dc.date.accessioned | 2018-02-22T07:06:07Z | - |
dc.date.available | 2018-02-22T07:06:07Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | CLINICAL & TRANSLATIONAL ONCOLOGY , 13, 10, 747-752 | en_US |
dc.identifier.issn | 1699-048X | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12094-011-0727-5 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/39787 | - |
dc.description.abstract | Background The purpose of this study was to evaluate telomerase activity in peripheral whole blood from head and neck squamous cell carcinoma (HNSCC) patients as a biomarker for diagnosis of HNSCC or detection of recurrence during follow-up.Materials and methods Telomerase activity was measured from peripheral whole blood extracts by telomerase repeat amplification protocol (TRAP) in HNSCC patients before and after surgery and in a control group. Sixty-two HNSCC patients and 42 control subjects were included. Results Telomerase activity was found in 41 out of 62 (66.1%) HNSCC patients before surgery and in 8 out of 42 (19.0%) controls (p<0.001). Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery. In follow-up, 6 out of 8 (75%) showed conversion of telomerase activity from negative to positive after recurrence. Telomerase activity was changed to negative in 4 out of 6 (66%) recurred patients with positive telomerase activity after second surgery. Conclusion The telomerase activity in peripheral whole blood extracts of HNSCC patients might be a useful biomarker for detecting recurrence after treatment. Further study with larger sample size using a more sensitive detection method of telomerase activity is necessary to verify these results. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA | en_US |
dc.subject | Telomerase | en_US |
dc.subject | Head and neck cancer | en_US |
dc.title | Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.1007/s12094-011-0727-5 | - |
dc.relation.page | 747-752 | - |
dc.relation.journal | CLINICAL & TRANSLATIONAL ONCOLOGY | - |
dc.contributor.googleauthor | Lee, Yong Seop | - |
dc.contributor.googleauthor | Tae, Kyung | - |
dc.contributor.googleauthor | Lee, Seung Hwan | - |
dc.contributor.googleauthor | Cho, Seok Hyun | - |
dc.contributor.googleauthor | Jeong, Jin Hyeok | - |
dc.contributor.googleauthor | Min, Hyun Jung | - |
dc.contributor.googleauthor | Ji, Yong Bae | - |
dc.relation.code | 2011217897 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | shcho | - |
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