Improving performance of a five-zone simulated moving bed chromatography for ternary separation by simultaneous use of partial-feeding and partial-closing of the product port in charge of collecting the intermediate-affinity solute molecules
- Title
- Improving performance of a five-zone simulated moving bed chromatography for ternary separation by simultaneous use of partial-feeding and partial-closing of the product port in charge of collecting the intermediate-affinity solute molecules
- Author
- 문성용
- Keywords
- Simulated moving bed chromatography; Ternary separation; Continuous separation process; Five-zone SMB
- Issue Date
- 2011-11
- Publisher
- Elsevier Science B.V.
- Citation
- Journal of Chromatography A, 2011, 1218(44), P.8060-8074
- Abstract
- The performance of a five-zone simulated moving bed (SMB) chromatographic process for ternary separation has been improved to a certain extent in previous researches by applying either a partial-feeding (PF) or a partial-closing of the extract-2 port (PCE(2)) to its operation. To make a further improvement, the strategy of applying both PF and PCE(2) simultaneously to the five-zone SMB operation was proposed in this study. The results from both equilibrium-theory analysis and detailed simulation proved that the proposed strategy, which was called PF-PCE(2) in this article, had the benefit of a synergy between the individual merits of PF and PCE(2) in the five-zone SMB performance. As a consequence, the PF-PCE(2) mode could surpass the PF and the PCE(2) modes by a wide margin and the standard mode by a much wider margin in the aspects of ternary-separation performance and throughput. For the separation system considered, the PF-PCE(2) mode was found to achieve more than 100% improvement, compared to the standard mode. Furthermore, such advantage of the PF-PCE(2) over all the other modes was greater as the selectivity between the intermediate-affinity and the highest-affinity components was reduced. (c) 2011 Elsevier B.V. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S002196731101363X?via%3Dihubhttp://hdl.handle.net/20.500.11754/37448
- ISSN
- 0021-9673; 1873-3778
- DOI
- 0.1016/j.chroma.2011.09.015
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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