THE EFFECTS OF SILDENAFIL CITRATE ON CHOROIDAL THICKNESS AS DETERMINED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
- Title
- THE EFFECTS OF SILDENAFIL CITRATE ON CHOROIDAL THICKNESS AS DETERMINED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
- Author
- 성민철
- Keywords
- central serous chorioretinopathy; choroidal thickness; enhanced depth imaging optical coherence tomography (OCT); sildenafil; spectral-domain OCT; CENTRAL SEROUS CHORIORETINOPATHY; OCULAR BLOOD-FLOW; RETINAL VASODILATATION; HEALTHY-SUBJECTS; VIAGRA; HEMODYNAMICS; CIRCULATION; INHIBITORS; PERFUSION; THERAPY
- Issue Date
- 2011-09
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
- Citation
- Retina, Vol.31, No.2 [2011], p332-335
- Abstract
- Purpose: To investigate the effects of the phosphodiesterase-5 inhibitor, sildenafil citrate, on choroidal thickness using eye-tracked enhanced depth imaging spectral-domain optical coherence tomography.Methods: In a prospective interventional study, 8 healthy subjects (4 men and 4 women) with no ocular history underwent enhanced depth imaging spectral-domain optical coherence tomography at baseline, 1 hour, and 3 hours after the ingestion of 100 mg of sildenafil citrate. Choroidal thickness measurements for both eyes using enhanced depth imaging spectral-domain optical coherence tomography were taken by 2 masked readers at baseline, 1-hour, and 3-hour time points. Statistical analysis was performed to compare the measurements of choroidal thickness at each of the three intervals.Results: The mean age of the subjects was 35.9 years (range 30-46 years). Mean choroidal thickness at baseline was 334 mu m (+/- 57 mu m). Mean choroidal thickness increased by 12.3% to 375 mu m (+/- 68 mu m) at 1 hour after ingestion (P < 0.001). At 3 hours after ingestion, the mean choroidal thickness remained elevated at 372 mu m (+/- 61 mu m), 11.6% thicker than baseline (P < 0.001). There was no significant difference in choroidal thickness between the 1-hour and the 3-hour intervals (P = 0.719).Conclusion: Sildenafil citrate appears to increase choroidal thickness as measured by eye-tracked enhanced depth imaging spectral-domain optical coherence tomography measurements in healthy subjects 1 hour and 3 hours after ingestion. These findings may be of relevance given that increased choroidal thickness appears to be a risk factor for central serous chorioretinopathy and that several reports have suggested an association between phosphodiesterase-5 inhibitors and this disorder.RETINA 31: 332-335, 2011
- URI
- http://insights.ovid.com/crossref?an=00006982-201102000-00018http://hdl.handle.net/20.500.11754/36983
- ISSN
- 0275-004X
- DOI
- 10.1097/IAE.0b013e3181eef0ae
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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