Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용석 | - |
dc.date.accessioned | 2018-02-08T05:03:01Z | - |
dc.date.available | 2018-02-08T05:03:01Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | PATHOLOGY INTERNATIONAL 권: 62 호: 3 페이지: 182-190 | en_US |
dc.identifier.issn | 1320-5463 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1827.2011.02776.x/abstract? | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36207 | - |
dc.description.abstract | Global histone modification patterns are presumed to establish epigenetic patterns of gene expression and determine the biology of the cell. In the present study, the global modification status of histone H3 and H4 was evaluated in 408 non-small cell lung cancer (NSCLC) tissues by immunostaining. NSCLC showed variable staining scores for each antibody. Clinicopathological analyses demonstrated a positive correlation between weak nuclear staining for H3K9Ac (P < 0.001), H3K9TriMe (P= 0.001), H4K16Ac (P < 0.001) and tumor recurrence except H4K20 TriMe (P= 0.201). Staining scores of four different antibodies were not correlated with other clinicopathologic variables. Patients were further clustered according to histone modification patterns: acetylation dominant, methylation dominant, co-dominant and modification-negative. The acetylation-dominant group (P= 0.009) and co-dominant group exhibited less frequent lymph node metastasis (P= 0.050), recurrence (P= 0.002) and distant metastasis (P= 0.010). The acetylation-dominant group showed better prognosis in survival analysis (P < 0.001, log-rank), whereas methylation-dominant and modification-negative status was associated with poor prognosis. In conclusion, our data suggest that global histone H3 and H4 modification patterns are potential markers of tumor recurrence and disease-free survival in NSCLC patients. | en_US |
dc.description.sponsorship | The authors thank Moo Song Lee, MD and Ms. Min Kyung Shin for their kind help with the statistical analyses. This work is supported by KOSEF research grant R01-2004-000-10670-0 and a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA | en_US |
dc.subject | acetylation | en_US |
dc.subject | histone | en_US |
dc.subject | methylation | en_US |
dc.subject | non-small cell lung cancer | en_US |
dc.subject | recurrence | en_US |
dc.title | Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 62 | - |
dc.identifier.doi | 10.1111/j.1440-1827.2011.02776.x | - |
dc.relation.page | 182-190 | - |
dc.relation.journal | PATHOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Song, Joon Seon | - |
dc.contributor.googleauthor | Kim, Yong Seok | - |
dc.contributor.googleauthor | Kim, Dong Kwan | - |
dc.contributor.googleauthor | Park, Sung Il | - |
dc.contributor.googleauthor | Jang, Se Jin | - |
dc.relation.code | 2012207441 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yongsk | - |
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