Genome-Wide Association Study of Rheumatoid Arthritis in Koreans
- Title
- Genome-Wide Association Study of Rheumatoid Arthritis in Koreans
- Author
- 이혜순
- Issue Date
- 2011-04
- Publisher
- American College of Rheumatology.
- Citation
- Arthritis & Rheumatism. Apr 01, 2011 63(4):884-893
- Abstract
- OBJECTIVE.: METHODS.: RESULTS.: Genome-wide significance (P < 5 × 10) was attained by markers from the major histocompatibility complex region and from the PADI4 gene. The replication data showed nominal association signals (P < 5 × 10) for markers from 11 of the 46 replicated loci, greatly exceeding random expectation. Genes that were most significant in the replication stage and in the combined analysis include the known European RA loci BLK, AFF3, and CCL21. Thus, in addition to the previously associated STAT4 alleles, variants at these three loci may contribute to RA not only among Europeans, but also among Asians. In addition, we observed replication signals near the genes PTPN2, FLI1, ARHGEF3, LCP2, GPR137B, TRHDE, and CGA1. Based on the excess of small P values in the replication stage study, we estimate that more than half of these loci are genuine RA susceptibility genes. Finally, we systematically analyzed the presence of association signals in Koreans at established European RA loci, which showed a significant enrichment of European RA loci among the Korean RA loci. CONCLUSION.
- URI
- https://onlinelibrary.wiley.com/doi/full/10.1002/art.23623
- ISSN
- 0004-3591
- DOI
- 10.1002/art.30235
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
- Juli-_et_al-2008-Arthritis_%26_Rheumatism.pdfDownload
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