Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태환 | - |
dc.date.accessioned | 2018-02-03T01:50:28Z | - |
dc.date.available | 2018-02-03T01:50:28Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | Journal of Rheumatic Diseases, 2011, 18(1), P.11-18 | en_US |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | http://kiss.kstudy.com/thesis/thesis-view.asp?key=2897959 | - |
dc.description.abstract | To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB) CD14+ osteoclast precursors. Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis, the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR. Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis-related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors. Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors. | en_US |
dc.description.sponsorship | 본 연구는 보건복지가족부 보건의료기술진흥사업의 지원에 의하여 이루어진 것임(과제고유번호 A084224). | en_US |
dc.language.iso | ko_KR | en_US |
dc.publisher | 대한류마티스학회 | en_US |
dc.subject | 류마티스관절염 | en_US |
dc.subject | 활액대식세포 | en_US |
dc.subject | 파골세포 | en_US |
dc.subject | 분화 | en_US |
dc.subject | 유전자 | en_US |
dc.subject | Synovial osteoclast precursors | en_US |
dc.subject | Osteoclastogenesis | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.title | 류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현 | en_US |
dc.title.alternative | Original Articles : Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 18 | - |
dc.relation.page | 11-8 | - |
dc.relation.journal | 대한류마티스학회지 | - |
dc.contributor.googleauthor | 이영호 | - |
dc.contributor.googleauthor | 김태환 | - |
dc.contributor.googleauthor | 최성재 | - |
dc.contributor.googleauthor | 송관규 | - |
dc.contributor.googleauthor | 지종대 | - |
dc.contributor.googleauthor | 이빛나라 | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Kim, Tae Hwan | - |
dc.contributor.googleauthor | Choi, Sung Jae | - |
dc.contributor.googleauthor | Song, Gwan Gyu | - |
dc.contributor.googleauthor | Ji, Jong Dae | - |
dc.contributor.googleauthor | Lee, Bit Na Ra | - |
dc.relation.code | 2012214945 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | thkim | - |
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