Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency

Title
Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency
Author
Ramakrishna, Suresh
Keywords
Embryonic stem cells; MiRNAs; Pluripotency; Reprogramming; Self-renewal
Issue Date
2016-03
Publisher
Springer Nature
Citation
Cell Regeneration, v. 5, NO 1, Article number 2
Abstract
Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19-24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Embryonic stem cells (ESCs) represent a valuable tool for disease modeling, drug discovery, developmental studies, and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency. Therefore, remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency. Here, we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming, as well as the potential role of miRNAs in two distinct pluripotent states (naïve and primed). © 2016 Lee et al.
URI
http://www.sciencedirect.com/science/article/pii/S2045976917300020?via%3Dihubhttp://hdl.handle.net/20.500.11754/34406
ISSN
2045-9769
DOI
10.1186/s13619-016-0028-0
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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