523 148

Full metadata record

DC FieldValueLanguage
dc.contributor.authorRamakrishna, Suresh-
dc.date.accessioned2018-01-30T04:36:59Z-
dc.date.available2018-01-30T04:36:59Z-
dc.date.issued2016-03-
dc.identifier.citationCell Regeneration, v. 5, NO 1, Article number 2en_US
dc.identifier.issn2045-9769-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S2045976917300020?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/34406-
dc.description.abstractIncreasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19-24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Embryonic stem cells (ESCs) represent a valuable tool for disease modeling, drug discovery, developmental studies, and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency. Therefore, remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency. Here, we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming, as well as the potential role of miRNAs in two distinct pluripotent states (naïve and primed). © 2016 Lee et al.en_US
dc.description.sponsorshipThis work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (2013K1A3A1A20046548) and the Ministry of Science, ICT and Future Planning (2015R1A4A1038666).en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectEmbryonic stem cellsen_US
dc.subjectMiRNAsen_US
dc.subjectPluripotencyen_US
dc.subjectReprogrammingen_US
dc.subjectSelf-renewalen_US
dc.titleDissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotencyen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume5-
dc.identifier.doi10.1186/s13619-016-0028-0-
dc.relation.page0-0-
dc.relation.journalCell Regeneration-
dc.contributor.googleauthorLee, Young Jin-
dc.contributor.googleauthorRamakrishna, Suresh-
dc.contributor.googleauthorChauhan, Himanshu-
dc.contributor.googleauthorPark, Won Sun-
dc.contributor.googleauthorHong, Seok-Ho-
dc.contributor.googleauthorKim, Kye-Seong-
dc.relation.code2016023276-
dc.sector.campusS-
dc.sector.daehakGraduate School of Biomedical Science & Engineering[S]-
dc.identifier.pidsuri28-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE