Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정목 | - |
dc.date.accessioned | 2018-01-25T02:05:17Z | - |
dc.date.available | 2018-01-25T02:05:17Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | GUT AND LIVER, v. 10, NO 2, Page. 228-236 | en_US |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl14472 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34381 | - |
dc.description.abstract | Background/Aims: To identify the risk factors for meta-chronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. Methods: We prospectively collected clinicopathologic data and measured the methylation levels of NANDI, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. Results: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 high-grade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sex matched patients without metachronous gastric neoplasms (p=0.020). Conclusions: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant for the Global Core Research Center (GCRC) funded by the Korea government (MSIP) (number: 2011-0030001). | en_US |
dc.language.iso | en | en_US |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | en_US |
dc.subject | Stomach neoplasms | en_US |
dc.subject | Metastasis | en_US |
dc.subject | Risk factors | en_US |
dc.subject | Therapeutics | en_US |
dc.title | Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.5009/gnl14472 | - |
dc.relation.page | 228-236 | - |
dc.relation.journal | GUT AND LIVER | - |
dc.contributor.googleauthor | Yoon, Hyuk | - |
dc.contributor.googleauthor | Kim, Nayoung | - |
dc.contributor.googleauthor | Shin, Cheol Min | - |
dc.contributor.googleauthor | Lee, Hye Seung | - |
dc.contributor.googleauthor | Kim, Bo Kyoung | - |
dc.contributor.googleauthor | Kang, Gyeong Hoon | - |
dc.contributor.googleauthor | Kim, Jung Mogg | - |
dc.contributor.googleauthor | Kim, Joo Sung | - |
dc.contributor.googleauthor | Lee, Dong Ho | - |
dc.contributor.googleauthor | Jung, Hyun Chae | - |
dc.relation.code | 2016005405 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jungmogg | - |
dc.identifier.orcid | http://orcid.org/0000-0002-6506-7519 | - |
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