128 0

A J-Shaped Association Between Serum Uric Acid Level and Allograft Outcomes After Living Donor Kidney Transplantation

Title
A J-Shaped Association Between Serum Uric Acid Level and Allograft Outcomes After Living Donor Kidney Transplantation
Author
박준성
Keywords
Graft survival; Kidney; Transplantation; Uric acid
Issue Date
2016-02
Publisher
WILEY-BLACKWELL
Citation
ARTIFICIAL ORGANS, v. 40, NO 2, Page. 136-143
Abstract
Hyperuricemia following kidney transplantation (KT) may contribute to a decline in allograft renal function, but be affected by KT-related confounding factors. Some studies have even suggested that a reduction in serum uric acid (UA) is associated with poor patient outcomes. Thus, we retrospectively analyzed the impact of serum UA on allograft outcomes in 281 KT recipients. KT recipients were divided into five groups according to serum UA level (mg/dL): Group I (n = 46), = 5; Group II (n = 62), > 5 and = 6; Group III (n = 70), > 6 and = 7; Group IV (n = 53), > 7 and = 8; Group V (n = 50), > 8. Regression analysis showed that serumUAlevel was significantly associated with future allograft function. In a Kaplan-Meier analysis, the dialysis-free survival of Group II recipients was better than that of the other groups (Group I, 140 +/- 5 months; Group II, 208 +/- 7 months; Group III, 148 +/- 4 months; Group IV, 185 +/- 12 months; Group V, 164 +/- 11 months; P = 0.0164). In Cox proportional hazard models adjusting for estimated glomerular filtration rate, the relative risk of allograft loss still tended to be elevated in Group I (HR=3.417, 95% CI 1.138-10.258) and Group V (HR= 2.793, 95% CI 1.108-7.041), using Group II as the reference. Our results suggest that there is a J-shaped association between serum UA levels and allograft outcomes in living donor KT recipients.
URI
http://onlinelibrary.wiley.com/doi/10.1111/aor.12519/abstracthttp://hdl.handle.net/20.500.11754/34104
ISSN
0160-564X; 1525-1594
DOI
10.1111/aor.12519
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE