Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-12-08T01:20:33Z | - |
dc.date.available | 2017-12-08T01:20:33Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | RHEUMATOLOGY, v. 55, NO 2, Page. 252-262 | en_US |
dc.identifier.issn | 1462-0324 | - |
dc.identifier.issn | 1462-0332 | - |
dc.identifier.uri | https://academic.oup.com/rheumatology/article/55/2/252/1822307 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34003 | - |
dc.description.abstract | Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. Methods. Patients in the Systemic Lupus International Collaborating Clinics inception cohort (<= 15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores. Results. There were 1827 patients, 89% females, mean (S.D.) age 35.1 (13.3) years. The mean (S.D.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) during follow-up. Patients with nephritis were younger, more frequently men and of African, Asian and Hispanic race/ethnicity. The estimated overall 10-year incidence of ESRD was 4.3% (95% CI: 2.8%, 5.8%), and with nephritis was 10.1% (95% CI: 6.6%, 13.6%). Patients with nephritis had a higher risk of death (HR = 2.98, 95% CI: 1.48, 5.99; P = 0.002) and those with eGFR <30 ml/min at diagnosis had lower SF-36 physical component summary scores (P<0.01) and lower Physical function, Physical role and Bodily pain scores. Over time, patients with abnormal eGFR and proteinuria had lower SF-36 mental component summary (P <= 0.02) scores compared to patients with normal values. Conclusion. LN occurred in 38.3% of SLE patients, frequently as the initial presentation, in a large multi-ethnic inception cohort. Despite current standard of care, nephritis was associated with ESRD and death, and renal insufficiency was linked to lower health-related quality of life. Further advances are required for the optimal treatment of LN. | en_US |
dc.description.sponsorship | The SLICC research network received funding for this study from Bristol-Myers Squibb. | en_US |
dc.language.iso | en | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.subject | systemic lupus erythematosus | en_US |
dc.subject | lupus | en_US |
dc.subject | nephritis | en_US |
dc.subject | inception cohort | en_US |
dc.subject | outcomes research | en_US |
dc.title | The frequency and outcome of lupus nephritis: results from an international inception cohort study | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 55 | - |
dc.identifier.doi | 10.1093/rheumatology/kev311 | - |
dc.relation.page | 252-262 | - |
dc.relation.journal | RHEUMATOLOGY | - |
dc.contributor.googleauthor | Hanly, John G. | - |
dc.contributor.googleauthor | O'Keeffe, Aidan G. | - |
dc.contributor.googleauthor | Su, Li | - |
dc.contributor.googleauthor | Urowitz, Murray B. | - |
dc.contributor.googleauthor | Romero-Diaz, Juanita | - |
dc.contributor.googleauthor | Gordon, Caroline | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Bernatsky, Sasha | - |
dc.contributor.googleauthor | Clarke, Ann E. | - |
dc.contributor.googleauthor | Wallace, Daniel J. | - |
dc.relation.code | 2016002789 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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