Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오재원 | - |
dc.date.accessioned | 2017-04-19T02:32:50Z | - |
dc.date.available | 2017-04-19T02:32:50Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.citation | CELLULAR IMMUNOLOGY, v. 298, NO 1-2, Page. 9-17 | en_US |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.issn | 1090-2163 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0008874915300095 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26804 | - |
dc.description.abstract | The purpose of this study was to identify the role of phospholipase D1 (PLD1) in Amb a 1-induced IL-5 and IL-13 expression. When BEAS-2B cells were stimulated with Amb a 1, PLD activity increased, and knockdown of PLD1 decreased Amb a 1-induced IL-5 and IL-13 expression. Amb a 1 also activated the PLC gamma/p70S6K/JNK pathway. Furthermore, Amb a 1-induced PLD activation was also attenuated by PLC gamma inhibition, and knockdown of PLD1 decreased Amb a 1-induced activation of P70S6K and JNK. When ATF-2 activity was blocked with ATF-2 siRNA, Amb a 1-induced IL-5 and IL-13 expression was completely abolished, indicating that ATF-2 is a transcriptional factor required for the expression of IL-5 and IL-13 in response to Amb a 1. Taken together, we suggest that PLD1 acts as an important regulator in Amb a 1-induced expression of IL-5 and IL-13 via a PLC gamma/p70S6K/JNK/ATF-2 pathway in BEAS-2B cells. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2013R1A2A2A03067895). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | en_US |
dc.subject | Ambrosia artemisiifolia | en_US |
dc.subject | PLD1 | en_US |
dc.subject | JNK | en_US |
dc.subject | p70S6K | en_US |
dc.subject | IL-13 | en_US |
dc.subject | IL-5 | en_US |
dc.title | PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 298 | - |
dc.identifier.doi | 10.1016/j.cellimm.2015.08.003 | - |
dc.relation.page | 9-17 | - |
dc.relation.journal | CELLULAR IMMUNOLOGY | - |
dc.contributor.googleauthor | Kim, Joo-Hwa | - |
dc.contributor.googleauthor | Choi, Hye-Jin | - |
dc.contributor.googleauthor | Oh, Cheong-Hae | - |
dc.contributor.googleauthor | Oh, Jae-Won | - |
dc.contributor.googleauthor | Han, Joong-Soo | - |
dc.relation.code | 2015000331 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jaewonoh | - |
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