Usefulness of B-mode and doppler sonography for the diagnosis of severe acute viral hepatitis A

Title
Usefulness of B-mode and doppler sonography for the diagnosis of severe acute viral hepatitis A
Authors
김용수
Keywords
hepatitis A virus; acute hepatitis; ultrasonography; Doppler; fulminant hepatic failure
Issue Date
2015-07
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CLINICAL ULTRASOUND, v. 43, NO 6, Page. 384-392
Abstract
BackgroundTo investigate B-mode and Doppler ultrasonography (US) features correlating with laboratory findings for the diagnosis of severe acute hepatitis (SAH) in patients with hepatitis A virus infection. MethodsThirty-nine consecutive serologically proven patients were enrolled. Decreased parenchymal echotexture, periportal tracking, gallbladder wall change, and splenomegaly were assessed on B-mode images. Blood flow velocities were measured in the main portal (V-PORTAL) and in the hepatic veins, and the hepatic venous pulsatility index was calculated. SAH was defined as high model for end-stage liver disease (MELD) score 15 with or without coagulopathy. The relationship between US features and laboratory findings was assessed, and SAH diagnosis was evaluated. ResultsSerum alanine transaminase and prothrombin time were significantly different depending on the presence of gallbladder wall change and splenomegaly (p˂0.05). V-PORTAL was inversely correlated with MELD score (r=-0.485) and several laboratory markers. The hepatic venous waveform and hepatic venous pulsatility index were significantly correlated with MELD score. For the diagnosis of SAH, the area under the receiver operating characteristic curve of V-PORTAL was 0.798. It reached 0.869 in the patients with typical GB change. ConclusionsBoth B-mode and Doppler US correlated well with several laboratory variables and may be helpful to diagnose SAH in patients with hepatitis A virus infection. (c) 2014 Wiley Periodicals, Inc.
URI
http://onlinelibrary.wiley.com/doi/10.1002/jcu.22234/fullhttp://hdl.handle.net/20.500.11754/26282
ISSN
0091-2751; 1097-0096
DOI
http://dx.doi.org/10.1002/jcu.22234
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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