Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians

Title
Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
Authors
최보율
Keywords
TYPE-2 DIABETES RISK; INSULIN-RESISTANCE; GLYCEMIC TRAITS; BETA-CELLS; LOCI; EXPRESSION; SECRETION; MASS
Issue Date
2015-07
Publisher
AMER DIABETES ASSOC
Citation
DIABETES, v. 64, no. 1, Page. 291-298
Abstract
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
URI
http://diabetes.diabetesjournals.org/content/early/2014/07/23/db14-0563.shorthttp://hdl.handle.net/20.500.11754/26228
ISSN
0012-1797; 1939-327X
DOI
http://dx.doi.org/10.2337/db14-0563
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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