Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
- Title
- Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians
- Author
- 최보율
- Keywords
- TYPE-2 DIABETES RISK; INSULIN-RESISTANCE; GLYCEMIC TRAITS; BETA-CELLS; LOCI; EXPRESSION; SECRETION; MASS
- Issue Date
- 2015-07
- Publisher
- AMER DIABETES ASSOC
- Citation
- DIABETES, v. 64, no. 1, Page. 291-298
- Abstract
- Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
- URI
- http://diabetes.diabetesjournals.org/content/early/2014/07/23/db14-0563.shorthttp://hdl.handle.net/20.500.11754/26228
- ISSN
- 0012-1797; 1939-327X
- DOI
- 10.2337/db14-0563
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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