Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승욱 | - |
dc.date.accessioned | 2017-03-17T01:22:32Z | - |
dc.date.available | 2017-03-17T01:22:32Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Korean Journal of Urology, v. 56, NO 7, Page. 505-514 | en_US |
dc.identifier.issn | 2005-6737 | - |
dc.identifier.issn | 2005-6745 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4111/kju.2015.56.7.505 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/26170 | - |
dc.description.abstract | Purpose: Heat shock protein (HSP) 27 protects the cell by controlling apoptosis and immune reactions, and c-FLIP (cellular-FLICE inhibitory protein) inhibits apoptosis by inhibiting caspase-8 activity. We investigated the relationship of HSP27 and c-FLIP expression to prostate-specific antigen, Gleason score sum (GSS), and pathologic stage. Materials and Methods: Samples from 163 patients between May 2004 and April 2010 were analyzed: 83 from patients that had underwent a radical prostatectomy, and 80 from those that underwent transurethral resection of the prostate to alleviate urinary symptoms from benign prostate hyperplasia. c-FLIP and HSP27 expression were observed by immunohistochemistry staining. Samples with less than 5% expression-positive cells were scored as 1, with 5%-50% were scored as 2, and with more than 50% were scored as 3. Local reactions were identified as 0.5 and evaluated. Results: Both the presence of HSP27 within the tumor and the number of cancer cells positive for HSP27 were significantly correlated to GSS and pathologic stage (p<0.001, p=0.001, p<0.001, p<0.001). The same was true for c-FLIP expression (p<0.001). GSS was more highly correlated to HSP27 expression than to c-FLIP expression (r=0.814 for HSP27, r=0.776 for c-FLIP), as was pathologic stage (r=0.592 for HSP27, r=0.554 for c-FLIP). Conclusions: In prostate cancer, higher GSS and a more advanced pathologic stage were associated with a higher likelihood of having a HSP27-positive tumor and more HSP27-positive tumor cells. HSP27 expression was correlated with GSS and prostate cancer stage. A more advanced pathologic stage corresponded to a higher likelihood of having a c-FLIP-positive tumor and more cFLIP-positive tumor cells. HSP27 expression had a higher correlation with prostate cancer stage and GSS than c-FLIP expression did. | en_US |
dc.description.sponsorship | This work was supported by BumSuk Academic Research Fund of 2010. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Urological Association | en_US |
dc.subject | Clinical pathology | en_US |
dc.subject | Heat-shock proteins | en_US |
dc.subject | Neoplasm grading | en_US |
dc.subject | Prostatic neoplasms | en_US |
dc.title | Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage. | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 56 | - |
dc.identifier.doi | 10.4111/kju.2015.56.7.505 | - |
dc.relation.page | 505-514 | - |
dc.relation.journal | Korean Journal of Urology | - |
dc.contributor.googleauthor | Lee, Seung Wook | - |
dc.contributor.googleauthor | Cho, Jeoung Man | - |
dc.contributor.googleauthor | Cho, Hee Ju | - |
dc.contributor.googleauthor | Kang, Jung Yoon | - |
dc.contributor.googleauthor | Kim, Eun Kyung | - |
dc.contributor.googleauthor | Yoo, Tag Keun | - |
dc.relation.code | 2015031559 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | swleepark | - |
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