Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종희 | - |
dc.date.accessioned | 2017-03-08T01:00:25Z | - |
dc.date.available | 2017-03-08T01:00:25Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013, 68(11), P.1326-1336 | en_US |
dc.identifier.issn | 0161-9152 | - |
dc.identifier.issn | 1574-4647 | - |
dc.identifier.uri | https://academic.oup.com/biomedgerontology/article/68/11/1326/624475 | - |
dc.description.abstract | Quantification of key outcome measures in animal models of aging is an important step preceding intervention testing. One such measurement, skeletal muscle power generation (force * velocity), is critical for dynamic movement. Prior research focused on maximum power (P-max), which occurs around 30-40 % of maximum load. However, movement occurs over the entire load range. Thus, the primary purpose of this study was to determine the effect of age on power generation during concentric contractions in the extensor digitorum longus (EDL) and soleus muscles over the load range from 10 to 90 % of peak isometric tetanic force (P-0). Adult, old, and elderly male C57BL/6 mice were examined for contractile function (6-7 months old, 100 % survival; similar to 24 months, 75 %; and similar to 28 months, < 50 %, respectively). Mice at other ages (5-32 months) were also tested for regression modeling. We hypothesized and found that power decreased with age not only at P-max but also over the load range. Importantly, we found greater age-associated deficits in both power and velocity when the muscles were contracting concentrically against heavy loads (> 50 % P-0). The shape of the force-velocity curve also changed with age (a/P-0 increased). In addition, there were prolonged contraction times to maximum force and shifts in the distribution of the myosin light and heavy chain isoforms in the EDL. The results demonstrate that age-associated difficulty in movement during challenging tasks is likely due, in addition to overall reduced force output, to an accelerated deterioration of power production and contractile velocity under heavily loaded conditions. | en_US |
dc.description.sponsorship | The authors thank the following individuals for their technical assistance: Windy Torgerud, Kelsey M Mosser, Haiming Liu, Rachel Borgstahl, Lisa Ferguson-Stegall, and David Nuckley. This study received the following funding: F31 AG044108 (Graber), T32 AG029796 (Thompson), R01 EY15313 (McLoon), and R01 AG017768 (Thompson). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Mice | en_US |
dc.subject | Sarcopenia | en_US |
dc.subject | Muscle | en_US |
dc.subject | Contractile physiology | en_US |
dc.subject | Power | en_US |
dc.subject | Velocity | en_US |
dc.title | C57BL/6 life span study: age-related declines in muscle power production and contractile velocity | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1007/s11357-015-9773-1 | - |
dc.relation.page | 1-16 | - |
dc.relation.journal | AGE | - |
dc.contributor.googleauthor | Graber, Ted G. | - |
dc.contributor.googleauthor | Kim, Jong-Hee | - |
dc.contributor.googleauthor | Grange, Robert W. | - |
dc.contributor.googleauthor | McLoon, Linda K. | - |
dc.contributor.googleauthor | Thompson, LaDora V. | - |
dc.relation.code | 2015012251 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ART AND PHYSICAL EDUCATION[S] | - |
dc.sector.department | DEPARTMENT OF PHYSICAL EDUCATION | - |
dc.identifier.pid | carachel07 | - |
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