Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜순 | - |
dc.date.accessioned | 2017-01-16T06:10:41Z | - |
dc.date.available | 2017-01-16T06:10:41Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY RESEARCH, v. 2015, NO 834085, Page. 1-15 | en_US |
dc.identifier.issn | 2314-8861 | - |
dc.identifier.issn | 2314-7156 | - |
dc.identifier.uri | https://www.hindawi.com/journals/jir/2015/834085/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/25179 | - |
dc.description.abstract | We have previously demonstrated that semimature dendritic cell- (smDC-) based immunotherapy is effective for the treatment of collagen-induced arthritis (CIA) prior to disease onset. In the present study, we examined the efficacy of combination therapy with smDCs and methotrexate (MTX) in advanced CIA with a score of 2-3. Combination therapy with low-dose MTX and type II collagen- (CII-) pulsed smDCs (CII-smDCs) was more effective in inhibiting disease progression than high or low-dose MTX alone or a combination of high dose MTX and CII-smDCs. The effect of CII-smDCs alone was also comparable to the combination therapy. CD4(+)Foxp3(+) Treg populations and IL-10 secretion markedly increased, and CII-specific autoreactive T cells decreased in mice treated with CII-smDCs alone or in combination with MTX. Combination therapy reduced the secretion of interferon-gamma (IFN-gamma) and IL-17 with little influence on the IL-4 secretion in the mixed leukocyte reaction. These results imply that the combination therapy with low-dose MTX and smDCs is effective in controlling advanced CIA by enhancing Treg population and suppresses antigen-specific Th1/Th17 immunity, rather than initiating Th1 to Th2 immune deviation. Our findings provide a better understanding of the DC therapy in combination with MTX for the treatment of patients with rheumatoid arthritis (RA). | en_US |
dc.description.sponsorship | This study was supported by a Bio New Drug Grant (A102130) from the Korean Ministry of Health and Welfare. | en_US |
dc.language.iso | en | en_US |
dc.publisher | HINDAWI PUBLISHING CORPORATION | en_US |
dc.subject | COLLAGEN-INDUCED ARTHRITIS | en_US |
dc.subject | TOLEROGENIC DENDRITIC CELLS | en_US |
dc.subject | RHEUMATOID-ARTHRITIS | en_US |
dc.subject | T-CELLS | en_US |
dc.subject | IN-VITRO | en_US |
dc.subject | NECROSIS FACTOR | en_US |
dc.subject | EXPRESS IL-4 | en_US |
dc.subject | THERAPY | en_US |
dc.subject | TOLERANCE | en_US |
dc.subject | INDUCTION | en_US |
dc.title | DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 834085 | - |
dc.relation.volume | 2015 | - |
dc.identifier.doi | 10.1155/2015/834085 | - |
dc.relation.page | 1-15 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Park, Jun-Eui | - |
dc.contributor.googleauthor | Jang, Jinah | - |
dc.contributor.googleauthor | Choi, Ji-Hye | - |
dc.contributor.googleauthor | Kang, Mi-sun | - |
dc.contributor.googleauthor | Woo, Yun-Ju | - |
dc.contributor.googleauthor | Seong, Young-Rim | - |
dc.contributor.googleauthor | Choi, Chan-Bum | - |
dc.contributor.googleauthor | Lee, Hye-Soon | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Bae, Yong-Soo | - |
dc.relation.code | 2015010253 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | lhsberon | - |
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