Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김한준 | - |
dc.date.accessioned | 2016-12-15T01:50:54Z | - |
dc.date.available | 2016-12-15T01:50:54Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | International Journal of Stem Cells, v. 8, NO 1, Page. 36-47 | en_US |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.issn | 2005-5447 | - |
dc.identifier.uri | http://www.ijstemcell.com/journal/view.html?doi=10.15283/ijsc.2015.8.1.36 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24863 | - |
dc.description.abstract | The liver is the largest organ in the body; it has a complex architecture, wide range of functions and unique regenerative capacity. The growing incidence of liver diseases worldwide requires increased numbers of liver transplant and leads to an ongoing shortage of donor livers. To meet the huge demand, various alternative approaches are being investigated including, hepatic cell transplantation, artificial devices and bioprinting of the organ itself. Adult hepatocytes are the preferred cell sources, but they have limited availability, are difficult to isolate, propagate poor and undergo rapid functional deterioration in vitro. There have been efforts to overcome these drawbacks; by improving culture condition for hepatocytes, providing adequate extracellular matrix, co-culturing with extra-parenchymal cells and identifying other cell sources. Differentiation of human stem cells to hepatocytes has become a major interest in the field of stem cell research and has progressed greatly. At the same time, use of decellularized organ matrices and 3 D printing are emerging cutting-edge technologies for tissue engineering, opening up new paths for liver regenerative medicine. This review provides a compact summary of the issues, and the locations of liver support systems and tissue engineering, with an emphasis on reproducible and useful sources of hepatocytes including various candidates formed by differentiation from stem cells. | en_US |
dc.description.sponsorship | This work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ0110022015)” Rural Development Administration, Republic of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Society for Stem Cell Research | en_US |
dc.subject | Hepatocyte | en_US |
dc.subject | Stem cells | en_US |
dc.subject | Liver | en_US |
dc.subject | Bioartificial liver | en_US |
dc.subject | Liver tissue engineering | en_US |
dc.subject | Bioprinting | en_US |
dc.title | Cell sources, liver support systems and liver tissue engineering: Alternatives to liver transplantation | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.15283/ijsc.2015.8.1.36 | - |
dc.relation.page | 36-47 | - |
dc.relation.journal | International Journal of Stem Cells | - |
dc.contributor.googleauthor | Lee, Soo Young | - |
dc.contributor.googleauthor | Kim, Han Joon | - |
dc.contributor.googleauthor | Choi, Dongho | - |
dc.relation.code | 2015027340 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | thicknyh | - |
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