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dc.contributor.author김정은-
dc.date.accessioned2016-11-04T06:25:21Z-
dc.date.available2016-11-04T06:25:21Z-
dc.date.issued2015-04-
dc.identifier.citation대한피부과학회지, v. 53, NO 4, Page. 277-283en_US
dc.identifier.issn0494-4739-
dc.identifier.urihttp://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=3323071-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/24163-
dc.description.abstractBackground: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. Objective: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. Methods: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. Results: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. Conclusion: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact.en_US
dc.language.isoko_KRen_US
dc.publisher대한피부과학회en_US
dc.subjectCyclosporineen_US
dc.subjectPsoriasisen_US
dc.subjectRecurrenceen_US
dc.title건선 환자에서 경구 Cyclosporine 치료 후 재발인자에 대한 연구en_US
dc.title.alternativeA Study on the Factors Causing Recurrence of Psoriasis after Cyclosporine Treatmenten_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume53-
dc.relation.page277-283-
dc.relation.journal대한피부과학회지-
dc.contributor.googleauthor문성훈-
dc.contributor.googleauthor김정은-
dc.contributor.googleauthor고주연-
dc.contributor.googleauthor노영석-
dc.contributor.googleauthorMoon, Seong Hun-
dc.contributor.googleauthorKim, Jeong Eun-
dc.contributor.googleauthorKo, Joo Yeon-
dc.contributor.googleauthorRo, Young Suck-
dc.relation.code2015041092-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.piddermakim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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