Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2016-10-31T05:59:36Z | - |
dc.date.available | 2016-10-31T05:59:36Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.citation | CLINICAL RHEUMATOLOGY, v. 34, NO 4, Page. 683-690 | en_US |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.issn | 1434-9949 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs10067-015-2904-3 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24024 | - |
dc.description.abstract | The aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin -1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841-1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052-1.198, p = 4.6 x 10(-5)). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041-1.189, p = 0.002). Furthermore, the prolactin -1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER LONDON LTD | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Prolactin | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.title | Meta-analysis of associations between functional prolactin-1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1007/s10067-015-2904-3 | - |
dc.relation.page | 683-690 | - |
dc.relation.journal | CLINICAL RHEUMATOLOGY | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Song, Gwan Gyu | - |
dc.relation.code | 2015009646 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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