SOFTWARE EYES FOR PROTEIN POST-TRANSLATIONAL MODIFICATIONS

Title
SOFTWARE EYES FOR PROTEIN POST-TRANSLATIONAL MODIFICATIONS
Author
백은옥
Keywords
post-translational modification; tandem mass spectrometry; computational proteomics; software
Issue Date
2015-03
Publisher
WILEY-BLACKWELL
Citation
MASS SPECTROMETRY REVIEWS, v. 34, NO 2, Page. 133-147
Abstract
Post-translational modifications (PTMs) are critical to almost all aspects of complex processes of the cell. Identification of PTMs is one of the biggest challenges for proteomics, and there have been many computational studies for the analysis of PTMs from tandem mass spectrometry (MS/MS). Most early PTM identification studies have been performed by matching MS/MS data to protein databases, using database search tools, but they are prohibitively slow when a large number of PTMs is given as a search parameter. In this article, we present recent developments to search for more types of PTMs and to speed up the search, and discuss many computational issues and solutions in terms of identifying multiply modified peptides or searching for all possible modifications at once in unrestrictive mode. Apart from the most common type of PTMs involving covalent addition of functional groups to proteins, PTMs such as disulfide linkage require dedicated software for the analysis because they may involve cross-linking between two different parts of proteins. Finally, methods for identification of protein disulfide bonds are presented. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 133-147, 2015.
URI
http://onlinelibrary.wiley.com/doi/10.1002/mas.21425/fullhttp://hdl.handle.net/20.500.11754/22973
ISSN
0277-7037; 1098-2787
DOI
10.1002/mas.21425
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > COMPUTER SCIENCE AND ENGINEERING(컴퓨터공학부) > Articles
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