Full metadata record

DC FieldValueLanguage
dc.contributor.author백은옥-
dc.date.accessioned2016-09-02T04:52:25Z-
dc.date.available2016-09-02T04:52:25Z-
dc.date.issued2015-03-
dc.identifier.citationMASS SPECTROMETRY REVIEWS, v. 34, NO 2, Page. 133-147en_US
dc.identifier.issn0277-7037-
dc.identifier.issn1098-2787-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/mas.21425/full-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/22973-
dc.description.abstractPost-translational modifications (PTMs) are critical to almost all aspects of complex processes of the cell. Identification of PTMs is one of the biggest challenges for proteomics, and there have been many computational studies for the analysis of PTMs from tandem mass spectrometry (MS/MS). Most early PTM identification studies have been performed by matching MS/MS data to protein databases, using database search tools, but they are prohibitively slow when a large number of PTMs is given as a search parameter. In this article, we present recent developments to search for more types of PTMs and to speed up the search, and discuss many computational issues and solutions in terms of identifying multiply modified peptides or searching for all possible modifications at once in unrestrictive mode. Apart from the most common type of PTMs involving covalent addition of functional groups to proteins, PTMs such as disulfide linkage require dedicated software for the analysis because they may involve cross-linking between two different parts of proteins. Finally, methods for identification of protein disulfide bonds are presented. (c) 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 133-147, 2015.en_US
dc.description.sponsorshipNational Research Foundation of Korea (NRF) - Korean Ministry of Education, Science and Technology NRF - Ministry of Science, ICT & Future Planning National Institute of General Medical Sciencesen_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectpost-translational modificationen_US
dc.subjecttandem mass spectrometryen_US
dc.subjectcomputational proteomicsen_US
dc.subjectsoftwareen_US
dc.titleSOFTWARE EYES FOR PROTEIN POST-TRANSLATIONAL MODIFICATIONSen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume34-
dc.identifier.doi10.1002/mas.21425-
dc.relation.page133-147-
dc.relation.journalMASS SPECTROMETRY REVIEWS-
dc.contributor.googleauthorNa, Seungjin-
dc.contributor.googleauthorPaek, Eunok-
dc.relation.code2015003456-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF COMPUTER SCIENCE-
dc.identifier.pideunokpaek-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > COMPUTER SCIENCE AND ENGINEERING(컴퓨터공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE