The Flavone Eupatilin Inhibits Eotaxin Expression in an NF-kappa B-Dependent and STAT6-Independent Manner

Title
The Flavone Eupatilin Inhibits Eotaxin Expression in an NF-kappa B-Dependent and STAT6-Independent Manner
Author
김정목
Keywords
BACTEROIDES-FRAGILIS ENTEROTOXIN; INTESTINAL EPITHELIAL-CELLS; INTERCELLULAR-ADHESION MOLECULE-1; PYLORI VACUOLATING CYTOTOXIN; ALLERGIC AIRWAY INFLAMMATION; CLOSTRIDIUM-DIFFICILE TOXIN; SEVERE ASTHMA; TNF-ALPHA; PATHWAY; EOSINOPHILS
Issue Date
2015-03
Publisher
WILEY-BLACKWELL
Citation
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v. 81, NO 3, Page. 166-176
Abstract
The CC chemokine eotaxin contributes to epithelium-induced inflammation in airway diseases such as asthma. Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone), a bioactive component of Artemisia asiatica Nakai (Asteraceae), is reported to inhibit the adhesion of eosinophils to bronchial epithelial cells. However, little is known about the molecular mechanism of eupatilin-induced attenuation of bronchial epithelium-induced inflammation. In this study, we investigated the effect of eupatilin on expression of eotaxin-1 (CCL11), a potent chemoattractant for eosinophils. Eupatilin significantly inhibited eotaxin expression in bronchial epithelial cells stimulated with TNF-, while NF-B and IB kinase (IKK) activities declined concurrently. Eupatilin also inhibited mitogen-activated protein kinase (MAPK) activity; however, all of these anti-inflammatory activities were reversed by MAPK overexpression. In contrast, eupatilin did not affect the signal transducer and activator of transcription 6 (STAT6) signalling in bronchial epithelial cells stimulated with IL-4. Furthermore, eupatilin significantly attenuated TNF--induced eosinophil migration. These results suggest that the eupatilin inhibits the signalling of MAPK, IKK, NF-B and eotaxin-1 in bronchial epithelial cells, leading to inhibition of eosinophil migration.
URI
http://onlinelibrary.wiley.com/doi/10.1111/sji.12263/fullhttp://hdl.handle.net/20.500.11754/22851
ISSN
0300-9475; 1365-3083
DOI
10.1111/sji.12263
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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