Tumor necrosis factor-alpha-308G/A의 유전적 다형성과 항결핵제 유발 반구진발진과의 연관성

Title
Tumor necrosis factor-alpha-308G/A의 유전적 다형성과 항결핵제 유발 반구진발진과의 연관성
Other Titles
Lack of associations between tumor necrosis factor-α genetic polymorphism -308G/A and antituberculous drug-induced maculopapular eruptio
Author
김상헌
Keywords
Genetic polymorphism; Tumor necrosis factor-alpha; Antitubercular agents; Drug eruption
Issue Date
2015-03
Publisher
대한 소아알레르기 호흡기학회/대한천식알레르기학회
Citation
Allergy Asthma & Respiratory Disease, v. 3, NO 2, Page. 124-127
Abstract
Purpose: Adverse cutaneous reactions to antituberculous drugs (ATD), such as maculopapular eruption (MPE), are the most common causes of discontinuation of scheduled treatment of tuberculosis. We previously reported that tumor necrosis factor (TNF)-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This study aimed to investigate associations between TNF-α -308G/A and ATD-induced MPE. Methods: Patients with ATD-induced MPE and controls without any adverse reactions to ATD were recruited from the database of the Adverse Drug Reaction Pharmacogenomic Research Group database of Korea. We compared the genotype frequency of TNF-α -308G/A between patients with ATD-induced MPE and ATD-tolerant controls. Results: A total of 69 patients with ATD-induced MPE and 229 control subjects were enrolled for this study. There were no significant differences in genotype frequency between the patients and the controls, suggesting lack of associations between TNF-α -308G/A and ATD-induced MPE. Conclusion: The TNF-α genetic polymorphism -308G/A may not be related to the development of ATD-induced MPE, in contrast to ATD-induced hepatitis. These findings suggest that associations between TNF-α -308G/A and ATD-induced adverse reactions can be phenotype-specific.
URI
http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=3311477http://hdl.handle.net/20.500.11754/22756
ISSN
2288-0402
DOI
10.4168/aard.2015.3.2.124
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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