Foxp3+ regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow

Title
Foxp3+ regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow
Authors
백두진
Keywords
B lymphopoiesis; Foxp3; Granulopoietins; Hematopoiesis; Regulatory T cells
Issue Date
2015-02
Publisher
WILEY-BLACKWELL
Citation
EUROPEAN JOURNAL OF IMMUNOLOGY, v. 45, Page. 167-179
Abstract
Foxp3 + Treg cells are crucial for maintaining T-cell homeostasis, but their role in B-cell homeostasis remains unclear. Here, we found that Foxp3 mutant scurfy mice had fewer B-lineage cells and progenitors, including common lymphoid progenitors and lymphoid- primed multipotent progenitors, but higher myeloid-lineage cell numbers in BM com- pared with WT littermates. Homeostasis within the HSC compartment was also com- promised with apparent expansion of long- and short-term HSCs. This abnormality was due to the lack of Treg cells, but not to the Treg-cell extrinsic functions of Foxp3 or cell- autonomous defects. Among cytokines enriched in the BM of scurfy mice, IFN-γ affected only B lymphopoiesis, but GM-CSF, TNF, and IL-6 collectively promoted granulopoiesis at the expense of B lymphopoiesis. Neutralization of these three cytokines reversed the hematopoietic defects on early B-cell progenitors in scurfy mice. Treg cells ensured B lymphopoiesis by reducing the production of these cytokines by effector T cells, but not by directly affecting B lymphopoiesis. These results suggest that Treg cells occupy an important niche in the BM to protect B-lineage progenitor cells from excessive exposure to a lymphopoiesis-regulating milieu.
URI
http://hdl.handle.net/20.500.11754/21821http://onlinelibrary.wiley.com/doi/10.1002/eji.201444532/abstract?systemMessage=Pay+Per+View+on+Wiley+Online+Library+will+be+unavailable+on+Saturday+15th+April+from+12%3A00-09%3A00+EDT+for+essential+maintenance.++Apologies+for+the+inconvenience.
ISSN
0014-2980
DOI
http://dx.doi.org/10.1002/eji.201444532
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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