Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김혁 | - |
dc.date.accessioned | 2016-06-08T02:45:16Z | - |
dc.date.available | 2016-06-08T02:45:16Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | CELL TRANSPLANTATION, Vol. 24, Page 2055-2064 | en_US |
dc.identifier.issn | 1555-3892 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/21563 | - |
dc.identifier.uri | http://www.ingentaconnect.com/content/cog/ct/2015/00000024/00000010/art00011 | - |
dc.description.abstract | Human amniotic epithelial cells (h-AECs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-AECs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-AECs express these pro-angiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-AECs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared the tissues of saline-treated rats. In conclusion, h-AECs secreted pro-angiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-AEC could regenerate myocardium tissue and improve cardiac function. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University HY-2013. The authors declare no conflicts of interest. | - |
dc.language.iso | en | en_US |
dc.publisher | COGNIZANT COMMUNICATION CORP | en_US |
dc.subject | Amniotic epithelial cells | en_US |
dc.subject | Myocardial infarction (MI) | en_US |
dc.subject | Paracrine | en_US |
dc.subject | Cytokine | en_US |
dc.title | Transplanted human amniotic epithelial cells secrete paracrine proangiogenic cytokines in rat model of myocardial infarction | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3727/096368914X685609 | - |
dc.relation.page | 1-27 | - |
dc.relation.journal | CELL TRANSPLANTATION | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | Joo, Hyun-Woo | - |
dc.contributor.googleauthor | Park, In-Hwa | - |
dc.contributor.googleauthor | Shen, Guang-Yin | - |
dc.contributor.googleauthor | Lee, Yonggu | - |
dc.contributor.googleauthor | Shin, Jeong Hun | - |
dc.contributor.googleauthor | Kim, Hyuck | - |
dc.contributor.googleauthor | Shin, Il-Seob | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.relation.code | 2015001645 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | khkim | - |
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