Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17)

Title
Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17)
Authors
Arne Holger Kutzner
Keywords
Ugene; FAM72A; In silico; 3D structure; Cancer; RSM
Issue Date
2015-01
Publisher
SPRINGER
Citation
TUMOR BIOLOGY, v. 36, NO 1, Page. 239-249
Abstract
FAM72A (p17) is a novel neuronal protein that has been linked to tumorigenic effects in non-neuronal tissue. Using state of the art in silico physicochemical analyses (e.g., I-TASSER, RaptorX, and Modeller), we determined the three-dimensional (3D) protein structure of FAM72A and further identified potential ligand-protein interactions. Our data indicate a Zn2+/Fe3+-containing 3D protein structure, based on a 3GA3_A model template, which potentially interacts with the organic molecule RSM ((2s)-2-(acetylamino)-N-methyl-4-[(R)-methylsulfinyl] butanamide). The discovery of RSM may serve as potential lead for further anti-FAM72A drug screening tests in the pharmaceutical industry because interference with FAM72A's activities via RSM-related molecules might be a novel option to influence the tumor suppressor protein p53 signaling pathways for the treatment of various types of cancers.
URI
http://hdl.handle.net/20.500.11754/21521https://link.springer.com/article/10.1007%2Fs13277-014-2620-7
ISSN
1010-4283
DOI
http://dx.doi.org/10.1007/s13277-014-2620-7
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEM(정보시스템학과) > Articles
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