Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2016-05-25T06:57:55Z | - |
dc.date.available | 2016-05-25T06:57:55Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | LUPUS, v. 24, NO 1, Page. 42-49 | en_US |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/21347 | - |
dc.identifier.uri | http://journals.sagepub.com/doi/10.1177/0961203314547791 | - |
dc.description.abstract | Objective Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. Methods Information and blood samples were obtained in a cross-sectional study from patients with SLE (n=308) and other rheumatologic diseases (n=389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA. Results Prevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR=2.7, 95% CI: 1.8-4, p˂0.001). Anti-C1q was associated with proteinuria (OR=3.0, 95% CI: 1.7-5.1, p˂0.001), red cell casts (OR=2.6, 95% CI: 1.2-5.4, p=0.015), anti-dsDNA (OR=3.4, 95% CI: 1.9-6.1, p˂0.001) and anti-Smith (OR=2.8, 95% CI: 1.5-5.0, p=0.01). Anti-C1q was independently associated with renal involvement after adjustment for demographics, ANA, anti-dsDNA and low complement (OR=2.3, 95% CI: 1.3-4.2, p˂0.01). Simultaneously positive anti-C1q, anti-dsDNA and low complement was strongly associated with renal involvement (OR=14.9, 95% CI: 5.8-38.4, p˂0.01). Conclusions Anti-C1q was more common in patients with SLE and those of Asian race/ethnicity. We confirmed a significant association of anti-C1q with renal involvement, independent of demographics and other serologies. Anti-C1q in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE PUBLICATIONS LTD | en_US |
dc.subject | Anti-dsDNA antibodies | en_US |
dc.subject | renal lupus | en_US |
dc.subject | systemic lupus erythematosus | en_US |
dc.title | Anti-C1q antibodies in systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 24 | - |
dc.identifier.doi | 10.1177/0961203314547791 | - |
dc.relation.page | 42-49 | - |
dc.relation.journal | LUPUS | - |
dc.contributor.googleauthor | Orbai, A-M | - |
dc.contributor.googleauthor | Truedsson, L | - |
dc.contributor.googleauthor | Sturfelt, G | - |
dc.contributor.googleauthor | Nived, O | - |
dc.contributor.googleauthor | Fang, H | - |
dc.contributor.googleauthor | Bae, S-C | - |
dc.contributor.googleauthor | Petri, M | - |
dc.relation.code | 2015003447 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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