Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용순 | - |
dc.date.accessioned | 2016-05-03T07:21:24Z | - |
dc.date.available | 2016-05-03T07:21:24Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | International Journal of Food Sciences and Nutrition, Volume 66, Issue 3, P. 308-313 | en_US |
dc.identifier.issn | 0963-7486 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/21073 | - |
dc.identifier.uri | http://www.tandfonline.com/doi/full/10.3109/09637486.2014.1000839 | - |
dc.description.abstract | The purpose of this study is to investigate that sorghum extract (SE) exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism-related protein expression. C57BL/6 mice were fed a modified AIN-93G diet (NC) with saline, or a modified AIN-93G diet with 2% cholesterol and 0.25% cholic acid with either saline (HC) or 600mg SE/kg body weight (HC-SE). Levels of total cholesterol and triglycerides in serum and liver were significantly lower in HC-SE than in HC. The expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase, sterol regulatory elementary binding protein2 and fatty acid synthase were significantly lower, whereas phosphorylated AMP-activated protein kinase expression was significantly higher in HC-SE than in HC. Cholesterol 7-a hydroxylase expression was also significantly higher in mice given SE than in those given HC. These results suggest that the cholesterol-lowering effect of SE may be related to the regulation of hepatic cholesterol metabolism in this mouse model. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INFORMA HEALTHCARE | en_US |
dc.subject | Hepatic protein expression | en_US |
dc.subject | high cholesterol | en_US |
dc.subject | mice | en_US |
dc.subject | sorghum | en_US |
dc.title | Sorghum extract exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism in hypercholesterolemic mice | en_US |
dc.type | Article | en_US |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.3109/09637486.2014.1000839 | - |
dc.relation.page | 1-6 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | - |
dc.contributor.googleauthor | Kim, Eunyoung | - |
dc.contributor.googleauthor | Kim, Sehee | - |
dc.contributor.googleauthor | Park, Yongsoo | - |
dc.relation.code | 2015013172 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF HUMAN ECOLOGY[S] | - |
dc.sector.department | MAJOR IN FOOD & NUTRITION | - |
dc.identifier.pid | yongsoon | - |
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