Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세용 | - |
dc.date.accessioned | 2024-03-05T04:53:48Z | - |
dc.date.available | 2024-03-05T04:53:48Z | - |
dc.date.issued | 2024-06-01 | - |
dc.identifier.citation | BIOSENSORS & BIOELECTRONICS | en_US |
dc.identifier.issn | 1873-4235 | en_US |
dc.identifier.issn | 0956-5663 | en_US |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0956566324001714 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/189475 | - |
dc.description.abstract | Eccrine sweat can serve as a source of biomarkers for assessing physiological health and nutritional balance, for tracking loss of essential species from the body and for evaluating exposure to hazardous substances. The growing interest in this relatively underexplored class of biofluid arises in part from its non-invasive ability for capture and analysis. The simplest devices, and the only ones that are commercially available, exploit soft microfluidic constructs and colorimetric assays with purely passive modes of operation. The most sophisticated platforms exploit batteries, electronic components and radio hardware for inducing sweat, for electrochemical evaluation of its content and for wireless transmission of this information. The work reported here introduces a technology that combines the advantages of these two different approaches, in the form of a cost-effective, easy-to-use device that supports on-demand evaluation of multiple biomarkers in sweat. This flexible, skin-interfaced, miniaturized system incorporates a hydrogel that contains an approved drug to activate eccrine sweat glands, electrodes and a simple circuit and battery to delivery this drug by iontophoresis through the surface of the skin, microfluidic channels and microreservoirs to capture the induced sweat, and multiple colorimetric assays to evaluate the concentrations of chloride, zinc, and iron. As demonstrated in healthy human participants monitored before and after a meal, such devices yield results that match those of traditional laboratory analysis techniques. Clinical studies that involve cystic fibrosis pediatric patients illustrate the use of this technology as a simple, painless, and reliable alternative to traditional hospital systems for measurements of sweat chloride. | en_US |
dc.description.sponsorship | This work was supported by the Querrey-Simpson Institute for Bioelectronics at Northwestern University. This work made use of the NUFAB facility of Northwestern University's NUANCE Center, which had received support from the SHyNE Resource (Grant No. NSF ECCS-2025633), the IIN, and the Northwestern's MRSEC program (Grant No. NSF DMR-1720139); the Keck Foundation. J.K. acknowledges additional support by KIST Institutional Program [Project No. 2E33141, and 2N70970], the Ministry of Science & ICT (MSIT) of Korea through National Research Foundation (Grant No. RS-2023-00211342), and grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HI19C1348). We also acknowledge the clinic study support from the Ann &Robert H. Lurie Children's Hospital. | en_US |
dc.language | en_US | en_US |
dc.publisher | ELSEVIER ADVANCED TECHNOLOGY | en_US |
dc.relation.ispartofseries | v. 253;116166-116176 | - |
dc.subject | Bioelectronics | en_US |
dc.subject | Sweat induction | en_US |
dc.subject | Sweat collection | en_US |
dc.subject | Health monitoring | en_US |
dc.title | A skin-interfaced, miniaturized platform for triggered induction, capture and colorimetric multicomponent analysis of microliter volumes of sweat | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.bios.2024.116166 | en_US |
dc.relation.page | 116166-116176 | - |
dc.relation.journal | BIOSENSORS & BIOELECTRONICS | - |
dc.contributor.googleauthor | Kim, Joohee | - |
dc.contributor.googleauthor | Oh, Seyong | - |
dc.contributor.googleauthor | Yang, Da Som | - |
dc.contributor.googleauthor | Rugg, Larissa | - |
dc.contributor.googleauthor | Mathur, Radhika | - |
dc.contributor.googleauthor | Kwak, Sung Soo | - |
dc.contributor.googleauthor | Yoo, Seonggwang | - |
dc.contributor.googleauthor | Li, Shupeng | - |
dc.contributor.googleauthor | Kanatzidis, Evangelos E. | - |
dc.contributor.googleauthor | Lee, Geumbee | - |
dc.relation.code | 2024003031 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | SCHOOL OF ELECTRICAL ENGINEERING | - |
dc.identifier.pid | seyongoh89 | - |
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