Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
- Title
- Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
- Author
- 정일엽
- Issue Date
- 2016-01
- Publisher
- 생화학분자생물학회
- Citation
- Experimental and Molecular Medicine, v. 48, article no. e202, Page. 1-10
- Abstract
- Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA-protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis.
- URI
- https://www.nature.com/articles/emm201596https://repository.hanyang.ac.kr/handle/20.500.11754/185114
- ISSN
- 1226-3613;2092-6413
- DOI
- 10.1038/emm.2015.96
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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