Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis
- Title
- Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis
- Author
- 김지원
- Issue Date
- 2022-03
- Publisher
- Royal Society of Chemistry
- Citation
- Journal of Materials Chemistry B, v. 10, NO. 10, Page. 1561-1570
- Abstract
- Tannic acid (TA) not only prevents drug carriers from sticking to the glycocalyx layer of vascular endothelial cells but also has anti-cancer properties, thereby improving drug delivery efficiency in cancer treatment. This study proposes a TANNylated nanovesicle-based cancer treatment approach by utilizing the aforementioned advantages of TA. We fabricated cancer cell-targeting BC71 peptide-conjugated TANNylated nanovesicles (TANV(BC71)) by covalently bonding the TA derivative and BC71 (cyclo[beta A-kRK(3-maleimidopropionyl)-d-(d-2-naphthyl)]) with thiol-modified phospholipids through the thiol-maleimide reaction. We demonstrated that TANV(BC71) was absorbed faster in high amounts by cancer cells than nanovesicles owing to its high affinity for the epidermal growth factor receptor and extracellular matrix components that are driven by van der Waals attraction as well as hydrogen bonding and hydrophobic interactions in a complex manner. These complex attractions of TANV(BC71) for cancer cells led to the effective induction of cancer cell apoptosis. The findings obtained in this study highlight that the TANV(BC71) system has the potential for intelligent high-efficacy cancer cell drug delivery.
- URI
- https://pubs.rsc.org/en/content/articlelanding/2022/TB/D1TB02509Khttps://repository.hanyang.ac.kr/handle/20.500.11754/184414
- ISSN
- 2050-7518;2050-750X
- DOI
- 10.1039/d1tb02509k
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > PHOTONICS AND NANOELECTRONICS(나노광전자학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML