Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5
- Title
- Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5
- Author
- 정일엽
- Keywords
- asthma; eosinophils; interferon-gamma; interleukin-5; interleukin-6; tumor necrosis factor
- Issue Date
- 2005-03
- Publisher
- S. Karger AG
- Citation
- International Archives of Allergy and Immunology, v. 136, NO. 3, Page. 295-302
- Abstract
- Background: Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential. Methods: In this study, we examined the ability of a number of cytokines to suppress the activation of eosinophils that function as effector cells for allergic airway diseases. Results: Interleukin (IL)-5, IL-6, and tumor necrosis factor (TNF) induced an eosinophil shape change, whereas interferon (IFN)-gamma significantly inhibited the shape change. Other cytokines, including IL-1, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-gamma effect, showing that pretreatment with IFN-gamma strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-gamma, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. In agreement with these results, IFN-gamma blocked the eosinophil migration and ERK phophorylation induced by IL-5, and the addition of CHX restored eosinophil chemotaxis. Conclusions: Collectively, IFN-gamma may attenuate eosinophilic inflammation by directly negating eosinophil mobilization. Copyright (C) 2005 S. Karger AG, Basel.
- URI
- https://www.karger.com/Article/FullText/83957https://repository.hanyang.ac.kr/handle/20.500.11754/183938
- ISSN
- 1018-2438;1423-0097
- DOI
- 10.1159/000083957
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > ETC
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