Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2023-07-17T01:11:08Z | - |
dc.date.available | 2023-07-17T01:11:08Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Biomedicines, v. 8, NO. 11, article no. 497, Page. 1-11 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://www.mdpi.com/2227-9059/8/11/497 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183736 | - |
dc.description.abstract | We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high gene-loading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | en | - |
dc.publisher | MDPI AG | - |
dc.subject | beta-glucan | - |
dc.subject | self-assembly | - |
dc.subject | nanomedicine | - |
dc.subject | siRNA | - |
dc.subject | gene delivery | - |
dc.title | Self-assembling β-glucan nanomedicine for the delivery of sirna | - |
dc.type | Article | - |
dc.relation.no | 11 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.3390/biomedicines8110497 | - |
dc.relation.page | 1-11 | - |
dc.relation.journal | Biomedicines | - |
dc.contributor.googleauthor | Lee, Kyungwoo | - |
dc.contributor.googleauthor | Min, Daejin | - |
dc.contributor.googleauthor | Choi, Yonghyun | - |
dc.contributor.googleauthor | Yoon, Semi | - |
dc.contributor.googleauthor | Jang, Jaehee | - |
dc.contributor.googleauthor | Hwang, Jangsun | - |
dc.contributor.googleauthor | Jeon, Hojeong | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.contributor.googleauthor | Choi, Jonghoon | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | ywcho7 | - |
dc.identifier.article | 497 | - |
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