Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2023-07-17T01:10:35Z | - |
dc.date.available | 2023-07-17T01:10:35Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.citation | MACROMOLECULAR RESEARCH, v. 30, NO. 2, Page. 85-89 | - |
dc.identifier.issn | 1598-5032;2092-7673 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s13233-022-0016-x | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183734 | - |
dc.description.abstract | Recently, plant-derived nanovesicles have attracted interest in the field of regenerative medicine because of their abundant immune-regulatory RNAs and phytochemicals with cell proliferation activity. However, the poor stability and rapid clearance of vesicles remain major challenges in their clinical applications. Herein, we report a facile method for surface modification of plant-derived nanovesicles by precipitation in the presence of poly(ethylene glycol) (PEG). We confirmed that PEGylation of nanovesicles slightly increased the particle size and zeta potential values. Importantly, this simple precipitation method produced PEGylated nanovesicles without any quantitative or qualitative loss of internal contents. When dispersed in PBS (pH 7.4), PEGylated nanovesicles did not exhibit a significant change in size for 24 h, indicating their high stability. Overall, our precipitation-based method is a useful technique for PEGylation of plant-derived nanovesicles without loss of bioactivity. | - |
dc.description.sponsorship | This work was supported by Korea Health Technology R&D Project (HI20C0437) of the Ministry of Health & Welfare, Basic Science Research Program (2020R1A6A3A01100335)throughthe National Research Foundation of Korea (NRF), Korea Basic Science Institute (National research Facilities and Equipment Center) grant funded by the Ministry of Education (2020R1A6C101A191), and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2021R1A4A1032782), Republic of Korea. | - |
dc.language | en | - |
dc.publisher | POLYMER SOC KOREA | - |
dc.subject | polyethylene glycol (PEG) | - |
dc.subject | extracellular vesicles | - |
dc.subject | plant nanovesicles | - |
dc.title | Precipitation-Mediated PEGylation of Plant-Derived Nanovesicles | - |
dc.type | Article | - |
dc.relation.no | 2 | - |
dc.relation.volume | 30 | - |
dc.identifier.doi | 10.1007/s13233-022-0016-x | - |
dc.relation.page | 85-89 | - |
dc.relation.journal | MACROMOLECULAR RESEARCH | - |
dc.contributor.googleauthor | Van Quy Nguyen | - |
dc.contributor.googleauthor | Um, Wooram | - |
dc.contributor.googleauthor | An, Jae Yoon | - |
dc.contributor.googleauthor | Joo, Hyeyeon | - |
dc.contributor.googleauthor | Choi, Young Chan | - |
dc.contributor.googleauthor | Jung, Jae Min | - |
dc.contributor.googleauthor | Choi, Ji Suk | - |
dc.contributor.googleauthor | You, Dong Gil | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.contributor.googleauthor | Park, Jae Hyung | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | ywcho7 | - |
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