Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2023-07-17T01:10:20Z | - |
dc.date.available | 2023-07-17T01:10:20Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.citation | ACS NANO, v. 16, NO. 1, Page. 251-260 | - |
dc.identifier.issn | 1936-0851;1936-086X | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acsnano.1c06096 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183733 | - |
dc.description.abstract | Hyaluronic acid-based hydrogels (Hyal-Gels) have the potential to reduce wrinkles by physically volumizing the skin. However, they have limited ability to stimulate collagen generation, thus warranting repeated treatments to maintain their volumizing effect. In this study, stem cell-derived extracellular vesicle (EV)-bearing Hyal-Gels (EVHyal-Gels) were prepared as a potential dermal filler, ameliorating the dermis microenvironment. No significant differences were observed in rheological properties and injection force between Hyal-Gels and EVHyal-Gels. When locally administered to mouse skin, Hyal-Gels significantly extended the biological halflife of EVs from 1.37 d to 3.75 d. In the dermis region, EVHyal-Gels induced the overexpression of CD301b on macrophages, resulting in enhanced proliferation of fibroblasts. It was found that miRNAs, such as let-7b-5p and miR-24-3p, were significantly involved in the change of macrophages toward the CD301b(hi) phenotype. The area of the collagen layer in EVHyal-Gel-treated dermis was 2.4-fold higher than that in Hyal-Gel-treated dermis 4 weeks after a single treatment, and the collagen generated by EVHyal-Gels was maintained for 24 weeks in the dermis. Overall, EVHyal-Gels have the potential as an antiaging dermal filler for reprogramming the dermis microenvironment. | - |
dc.description.sponsorship | Basic Science Research Programs of the National Research Foundation (NRF) [2018R1A2B3006080, 2021R1A4A1032782]; Korean Fund for Regenerative Medicine of the National Research Foundation (NRF) [2021M3E5E5096677]; Korea Basic Science Institute (National Research Facilities and Equipment Center) grant from the Ministry of Education [2020R1A6C101A191]; Korea Health Technology R&D Project of the Ministry of Health & Welfare, Republic of Korea [HI20C2113] | - |
dc.language | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | extracellular vesicles | - |
dc.subject | CD301(bhi) macrophage | - |
dc.subject | hyaluronic acid | - |
dc.subject | hydrogel | - |
dc.subject | dermal filler | - |
dc.title | Stem Cell-Derived Extracellular Vesicle-Bearing Dermal Filler Ameliorates the Dermis Microenvironment by Supporting CD301b-Expressing Macrophages | - |
dc.type | Article | - |
dc.relation.no | 1 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.1021/acsnano.1c06096 | - |
dc.relation.page | 251-260 | - |
dc.relation.journal | ACS NANO | - |
dc.contributor.googleauthor | You, Dong Gil | - |
dc.contributor.googleauthor | An, Jae Yoon | - |
dc.contributor.googleauthor | Um, Wooram | - |
dc.contributor.googleauthor | Jung, Jae Min | - |
dc.contributor.googleauthor | Oh, Byeong Hoon | - |
dc.contributor.googleauthor | Van Quy Nguyen | - |
dc.contributor.googleauthor | Jeon, Jueun | - |
dc.contributor.googleauthor | Lee, Jungmi | - |
dc.contributor.googleauthor | Jo, Dong-Gyu | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.contributor.googleauthor | Park, Jae Hyung | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | ywcho7 | - |
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