Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문효방 | - |
dc.date.accessioned | 2023-06-22T02:58:35Z | - |
dc.date.available | 2023-06-22T02:58:35Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | SCIENCE OF THE TOTAL ENVIRONMENT, v. 803, article no. 149969, Page. 1.0-9.0 | - |
dc.identifier.issn | 0048-9697;1879-1026 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0048969721050440?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/182251 | - |
dc.description.abstract | In this study, we identified major aryl hydrocarbon receptor (AhR) agonists in the sediments from Yeongil Bay (n = 6) using effect-directed analysis. Using the H4IIE-luc bioassays, great AhR-mediated potencies were found in aro-matic fractions (F2) of sediment organic extracts from silica gel column chromatography and sub-fractions (F2.6- F2.8) from reverse phase-HPLC. Full-scan mass spectrometric analysis using GC-QTOFMS was conducted to identify novel AhR agonists in highly potent fractions, such as F2.6-F2.8 of S1 (Gumu Creek). Selection criteria for AhR-active compounds consisted of three steps, including matching factor of NIST library (>_70), aromatic structures, and the number of aromatic rings (>_4). Fifty-nine compounds were selected as tentative AhR agonist candidates, with the AhR-mediated activity being assessed for six compounds for which standard materials were available commercially. Of these compounds, 20-methylcholanthrene, 7-methylbenz[a]anthracene, 10-methylbenz[a]pyrene, and 7,12-dimethylbenz[a]anthracene exhibited significant AhR-mediated potency. Relative potency values of these com-pounds were determined relative to benzo[a]pyrene to be 3.2, 1.4, 1.2, and 0.2, respectively. EPA positive matrix fac-torization modeling indicated that the sedimentary AhR-active aromatic compounds primarily originated from coal combustion and vehicle emissions. Potency balance analysis indicated that four novel AhR agonists explained 0.007% to 1.7% of bioassay-derived AhR-mediated potencies in samples. (c) 2021 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | National Research Foundation of KoreaNational Research Foundation of Korea [2016R1E1A1A01943004, 2020R1A4A2002823, 2021R1C1C1005977]; Ministry of Oceans and Fisheries of Korea [20140342, 20210427]; Canada Research Chair programCanada Research Chairs; Baylor University | - |
dc.language | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | Aryl hydrocarbon receptor | - |
dc.subject | H4IIE-luc bioassay | - |
dc.subject | GC-QTOFMS | - |
dc.subject | Full-scan screening analysis | - |
dc.subject | Industrial area | - |
dc.title | Effect-directed identification of novel aryl hydrocarbon receptor-active aromatic compounds in coastal sediments collected from a highly industrialized area | - |
dc.type | Article | - |
dc.relation.volume | 803 | - |
dc.identifier.doi | 10.1016/j.scitotenv.2021.149969 | - |
dc.relation.page | 1.0-9.0 | - |
dc.relation.journal | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.contributor.googleauthor | Gwak, Jiyun | - |
dc.contributor.googleauthor | Cha, Jihyun | - |
dc.contributor.googleauthor | Lee, Junghyun | - |
dc.contributor.googleauthor | Kim, Youngnam | - |
dc.contributor.googleauthor | An, Seong-Ah | - |
dc.contributor.googleauthor | Lee, Sunggyu | - |
dc.contributor.googleauthor | Moon, Hyo-Bang | - |
dc.contributor.googleauthor | Hur, Jin | - |
dc.contributor.googleauthor | Giesy, John P. | - |
dc.contributor.googleauthor | Hong, Seongjin | - |
dc.contributor.googleauthor | Khim, Jong Seong | - |
dc.sector.campus | E | - |
dc.sector.daehak | 과학기술융합대학 | - |
dc.sector.department | 해양융합공학과 | - |
dc.identifier.pid | hbmoon | - |
dc.identifier.article | 149969 | - |
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